托吡酯治疗脑梗死后继发癫痫对患者神经功能及生活活动能力的影响探讨  

Effect of topiramate on neurological function and activities of life in patients with post-cerebral infarction epilepsy

作　　者：张文政 黄登学 徐西朋 ZHANG Wen-zheng;HUANG Deng-xue;XU Xi-peng(Department of Internal Medicine Neurology,Liangshan County People’s Hospital,Jining 272600,China)

机构地区：[1]济宁梁山县人民医院神经内科,272600 [2]济宁梁山县人民医院急诊内科,272600

出　　处：《中国实用医药》2020年第28期121-123,共3页China Practical Medicine

摘　　要：目的探讨托吡酯治疗脑梗死后继发癫痫(PIE)的临床疗效及对患者神经功能和生活活动能力的影响。方法92例脑梗死后继发癫痫患者,根据随机数字表法分为试验组和对照组,各46例。对照组患者给予卡马西平治疗,试验组给予托吡酯治疗。观察比较两组临床疗效及治疗前后脑电图异常率、神经功能缺损情况和日常生活活动能力。结果试验组总有效率为93.48%(43/46),明显高于对照组的78.26%(36/46),差异具有统计意义(P<0.05)。治疗后,两组脑电图异常率均低于治疗前,且试验组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组美国国立卫生研究院卒中量表(NIHSS)评分和Barthel指数均优于治疗前,且试验组NIHSS评分(9.18±2.45)分和Barthel指数(89.76±6.74)分优于对照组的(13.48±2.79)、(77.04±6.28)分,差异有统计学意义(P<0.05)。结论托吡酯治疗脑梗死后继发癫痫临床效果较好,可明显改善脑电图、神经功能以及日常生活活动能力,值得推广应用。Objective To discuss the effect of topiramate on neurological function and activities of life in patients with post-cerebral infarction epilepsy(PIE).Methods A total of 92 patients with post-infarction epilepsy were divided into experimental group and control group according to random numerical table,with 46 cases in each group.The control group was treated with carbamazepine,and the experimental group was treated with topiramate.The clinical efficacy,abnormal rate of electroencephalogram,neurological deficits and activities of daily living before and after treatment were observed and compared between the two groups.Results The total effective rate of the experimental group was 93.48%(43/46),which was obviously higher than 78.26%(36/46)of the control group,and the difference was statistically significant(P<0.05).After treatment,the abnormal rate of electroencephalogram of the two groups were lower than those before treatment,and the experimental group was lower than the control group,and the difference was statistically significant(P<0.05).After treatment,the National Institutes of Health stroke scale(NIHSS)score and Barthel index of the two groups were better than those before treatment,and the NIHSS score(9.18±2.45)points and Barthel index(89.76±6.74)points of the experimental group were better than(13.48±2.79)and(77.04±6.28)points of the control group,and the difference was statistically significant(P<0.05).Conclusion Topiramate has good clinical effect in the treatment of post-cerebral infarction epilepsy,and it can obviously improve electroencephalogram,neurological function and activities of daily living,which is worthy of promotion and application.

关 键 词：托吡酯 脑梗死后继发癫痫 神经功能 生活活动能力 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R743.3[医药卫生—临床医学]