NK细胞的生物学特性及其在B细胞淋巴瘤应用中的研究进展  

Research Progress on Biological Properties of Natural Killer Cells and Their Application in B Cell Lymphoma——Review

作　　者：喻敏[1] 康晶 陈志未 李菲[1] YU Min;KANG Jing;CHEN Zhi-Wei;LI Fei(Department of Hematology,The First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China)

机构地区：[1]南昌大学第一附属医院血液科,江西南昌330006

出　　处：《中国实验血液学杂志》2020年第5期1782-1786,共5页Journal of Experimental Hematology

摘　　要：B细胞淋巴瘤是一组起源于淋巴组织、具有不同临床表现和生物学特征的恶性增殖性疾病,可发生于身体任何部位,占全部淋巴瘤的80%以上。NK细胞是固有免疫系统的重要组成细胞,无需预先致敏就可对肿瘤和被病毒感染的靶细胞产生快速应答,在机体免疫的早期发挥重要的监视作用。有研究表明,NK细胞在B细胞淋巴瘤的发生、发展及治疗中一直起到重要的作用,临床上可通过改善和提高NK细胞功能来抑制B细胞淋巴瘤的发生发展。本文就NK细胞的生物学特性及其在B细胞淋巴瘤中的作用和应用作一综述。B cell lymphoma is a group of very heterogeneous biologically complex malignancies,which originates from lymph nodes with different kinds of clinical and biologic characteristics.B cell lyphoma can occur in every part of body,and accouting for more than 80%of cell lyphomas.Natural killer(NK)is the impartant composition cell of immune system,which can fast response to the targeting cells,such as tumour cells or cells infected by virus without sensitization,NK cells play an important role in the early innate immunity.Compelling evidences shows that NK cells play an important role in occurrence,development and treatment of B cell lyphoma,and B cell lymphoma can be inhibitied by advanced and impoved NK cells.In this review,the biologic characteristics and role of NK cells in B cell lyphoma was summrized briefly.

关 键 词：NK细胞 B细胞淋巴瘤 临床应用 研究进展 

分 类 号：R733.4[医药卫生—肿瘤] R329[医药卫生—临床医学]