慢性失眠患者大脑白质结构变化的磁共振成像研究  

Magnetic resonance imaging study of white matter structure changes in patients with chronic insomnia

作　　者：秦贺 刘波[2] 喻大华[3] QIN He;LIU Bo;YU Dahua(Department of Neurology,the Affiliated Hospital of Inner Mongolia University for Nationalities,Tongliao,Inner Mongolia Autonomous Region 028000,China;Department of Neurology,the First Affiliated Hospital of Baotou Medical College,Baotou,Inner Mongolia Autonomous Region 014010,China;Key Laboratory of Pattern Recognition and Intelligent Image Processing,Inner Mongolia University of Science and Technology,Baotou,Inner Mongolia Autonomous Region 014010,China)

机构地区：[1]内蒙古民族大学附属医院神经内科,内蒙古通辽028000 [2]包头医学院第一附属医院神经内科,内蒙古包头014010 [3]内蒙古科技大学内蒙古自治区模式识别与智能图像处理重点实验室,内蒙古包头014010

出　　处：《实用放射学杂志》2020年第10期1533-1536,共4页Journal of Practical Radiology

基　　金：国家自然科学基金面上项目(81571753,81871430);内蒙古自然科学基金面上项目(2018LH08079)。

摘　　要：目的探讨慢性失眠患者脑白质微观结构的改变。方法对35例慢性失眠患者(失眠组)和35例正常睡眠(对照组)进行DTI扫描,使用基于体素的分析方法(VBA)比较2组脑白质FA值。结果与对照组比较,失眠组的白质FA值降低的脑区主要集中于外囊和钩状束,其次还存在于海马旁回、杏仁核及脑岛周边的脑组织(P<0.05,FWE校正)。结论慢性失眠患者的外囊、钩状束、海马旁回、杏仁核及脑岛周边脑组织等脑区的白质纤维束完整性发生变化,这些脑区主要与情绪或认知障碍有关,可能是慢性失眠发病机制的关键所在。Objective To explore the changes of brain white matter microstructure in patients with chronic insomnia.Methods DTI scans were performed on 35 cases of chronic insomnia(insomnia group)and 35 cases of normal sleep(control group).Voxe-l based analysis(VBA)was used to compare the white matter FA.Results Compared with the control group,the brain regions with reduced white matter FA values in the insomnia group were mainly concentrated in the outer capsule and the hooked bundle,and secondly in the brain tissues around the hippocampus,amygdala and cerebral islets(P<0.05,FWE correction).Conclusion The integrity of the white matter fiber bundles in the brain regions of patients with chronic insomnia,such as the outer capsule and the hooked bundle,and secondly in the brain tissues around the hippocampus,amygdala,and cerebral islets,has changed,these brain regions are mainly related to emotional or cognitive disorders,which may be the key to the pathogenesis of chronic insomnia.

关 键 词：慢性失眠 白质 磁共振成像 基于体素的分析方法 

分 类 号：R749.99[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]