铁、钴、铜酞菁催化2-氨基苯甲醇氧化制备喹唑啉和喹啉  

Phathalocyanine Metal Complexes(M=Fe,Co,and Cu)Catalyzed Aerobic Oxidation of 2-Amino-benzyl Alcohols to Access Quinazolines and Quinolines

作　　者：刘子琳 张小洁 张恒 姜辉 赵雪梅[1] 石林林 朱新举 郝新奇[1] 宋毛平[1] Liu Zilin;Zhang Xiaojie;Zhang Heng;Jiang Hui;Zhao Xuemei;Shi Linlin;Zhu Xinju;Hao Xinqi;Song Maoping(College of Chemistry,Zhengzhou University,Zhengzhou 450001)

机构地区：[1]郑州大学化学学院,郑州450001

出　　处：《有机化学》2020年第9期2755-2763,共9页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21672192,21803059,U1904212,21929101)资助项目.

摘　　要：酞菁金属络合物在空气中催化2-氨基苄醇与腈和酮的氧化缩合反应,分别制得喹唑啉和喹啉.经过系统研究发现,铁(II)酞菁在喹唑啉合成中显示出较高的催化活性,而铜(II)酞菁在喹啉制备中显示出较高的催化活性.在优化的条件下,各种腈和酮具有良好的适应性,从而以高收率得到相应的产物.Phathalocyanine metal complexes catalyzed oxidative condensation of 2-aminobenzyl alcohols with nitriles and ketones has been developed under air to afford quinazolines and quinolines,respectively.After systematic investigation,iron(II)phathalocyanine displayed higher catalytic activity in quinazoline synthesis and copper(II)phathalocyanine showed higher efficiency in quinoline preparation.Under the optimized conditions,various nitriles and ketones were well adaptted to give the corresponding products in good yields.

关 键 词：金属酞菁 喹唑啉 喹啉 有氧氧化 

分 类 号：O626[理学—有机化学]