内镜逆行胰胆管造影术后并发胰腺炎的危险因素  

Risk factors associated with postoperative pancreatitis of endoscopic retrograde cholangiopancreatography

作　　者：王平[1] 葛建新[1] 黄晓丽[1] WANG Ping;GE Jianxin;HUANG Xiaoli(Department of Gastroenterology,Nanjing Jiangbei Hospital,Nantong University,Nanjing 210048,China)

机构地区：[1]南通大学附属南京江北医院消化内科,南京210048

出　　处：《临床与病理杂志》2020年第10期2594-2598,共5页Journal of Clinical and Pathological Research

摘　　要：目的:分析内镜逆行胰胆管造影术(endoscopic retrograde cholangiopancreatography,ERCP)术后并发胰腺炎的危险因素。方法:纳入2015年1月至2019年12月在南通大学附属南京江北医院接受ERCP手术治疗的患者440例作为研究对象,回顾性分析患者的临床资料,单因素分析筛选ERCP术后并发胰腺炎的危险因素,多因素logistic回归模型分析ERCP术后并发胰腺炎的独立危险因素。结果:在440例患者中,39例患者ERCP术后发生胰腺炎,发生率为8.86%。单因素分析结果显示ERCP术后胰腺炎的发生与患者插管频次、造影剂注射频次、括约肌功能障碍和鼻胆管引流密切相关(P<0.05),而与患者年龄、性别、BMI、黄疸和麻醉方法无明显相关性(P>0.05)。多因素logistic回归分析显示插管频次、造影剂注射频次、括约肌功能障碍和鼻胆管引流是ERCP术后并发胰腺炎的独立危险因素(P<0.05)。结论:插管频次、造影剂注射频次、括约肌功能障碍和鼻胆管引流是ERCP术后并发胰腺炎的危险因素,可制订针对性预防对策,提高患者预后。Objective:To investigate the risk factors associated with pancreatitis after endoscopic retrograde cholangiopancreatography(ERCP).Methods:A total of 440 patients,who underwent ERCP at our hospital from January 2015 to December 2019,were enrolled in this study.The clinical data were analyzed retrospectively,and the risk factors associated with postoperative pancreatitis were screened and identified by using univariate analysis and multivariate logistic regression analysis.Results:In 440 patients,39 patients developed pancreatitis after ERCP,yielding a postoperative pancreatitis incidence of 8.86%.Univariate analysis showed that intubation frequency,contrast injection frequency,sphincter dysfunction,and nasal bile duct drainage were closely associated with postoperative pancreatitis(P<0.05).And there was no relationship between age,gender,BMI,jaundice,and anesthesia method and postoperative pancreatitis(P>0.05).Multivariate logistic regression analysis indicated that intubation frequency,contrast injection frequency,sphincter dysfunction,and nasal bile duct drainage were independent risk factors associated with postoperative pancreatitis(P<0.05).Conclusion:Intubation frequency,contrast injection frequency,sphincter dysfunction,and nasal bile duct drainage are independent risk factors associated with postoperative pancreatitis.And targeted preventive measures should be made to improve the prognosis.

关 键 词：内镜逆行胰胆管造影术 胰腺炎 危险因素 预防 

分 类 号：R576[医药卫生—消化系统]