结直肠癌MSCT灌注参数与其临床分期、EGFR及MVD表达的相关性  

Correlation between MSCT Perfusion Parameters and Clinical Stage,EGFR and MVD Expression in Colorectal Cancer

作　　者：吴倩 曾杰 熊丹 程琳 WU Qian;ZENG Jie;XIONG Dan(Department of Radiology,Southwest Hospital,Army Medical University,Chongqing 400030,China)

机构地区：[1]陆军军医大学附属西南医院放射科,重庆400030

出　　处：《中国CT和MRI杂志》2020年第12期132-134,共3页Chinese Journal of CT and MRI

基　　金：重庆市社会事业与民生保障科技创新课题(编号:cstc2017shms-kjfp0339)。

摘　　要：目的探讨结直肠癌MSCT灌注参数与其临床分期、表皮生长因子受体(EGFR)及肿瘤微血管密度(MVD)表达的相关性。方法回顾性分析本院2017年7月至2019年8月收治的48例结直肠癌患者的临床资料,将MSCT检查结果进行分析和讨论,分析其灌注参数与临床病理分期、MVD、EGFR的相关性。结果TNM分期越高,灌注参数BV数值与BF数值越低;TTP数值和PS数值越高。其中TNM分期中,各期之间的BF、TTP、PS数值比较差异具有统计学意义(P<0.05)。各期之间的BV数值比较差异无统计学意义(P>0.05)。EGFR、MVD与灌注参数BV、BF、TTP、PS数值之间均无明显相关性。结论MSCT灌注成像BV、BF、TTP、PS与EGFR、MVD之间未见明确相关性,但与结直肠癌TNM分期具有一定的相关性,通过分析灌注成像水平,可一定程度上提示结直肠癌临床分期。Objective To investigate the correlation between MSCT perfusion parameters of colorectal cancer and clinical stage,epidermal growth factor receptor(EGFR)and microvessel density(MVD)expression.Methods The clinical data of 48 patients with colorectal cancer admitted to our hospital from July 2017 to August 2019 were analyzed retrospectively.The results of MSCT examination were analyzed and discussed.The correlation between perfusion parameters and clinical pathological stage,MVD and EGFR was analyzed.Results The higher the TNM stage was,the lower the BV value and the BF value of the perfusion parameter were,the higher the TTP value and the PS value were.Among the TNM staging,the difference in BF,TTP and PS between the each stage was statistically significant(P<0.05).There was no significant difference in the BV values between the each stage(P>0.05).There was no significant correlation between EGFR,MVD and perfusion parameters BV,BF,TTP and PS values.Conclusion There was no clear correlation between BV,BF,TTP,PS and EGFR and MVD in MSCT perfusion imaging,but BV,BF,TTP,PS had a certain correlation with TNM staging of colorectal cancer.By analyzing the level of perfusion imaging,it may help to suggest the clinical stage of colorectal cancer.

关 键 词：结直肠癌 MSCT灌注参数 临床分期 肿瘤微血管密度 表皮生长因子受体 

分 类 号：R735[医药卫生—肿瘤]