人体肠道耐药基因组的研究进展  

Advances in Human Gut Resistome

作　　者：段宇婧 吴新颜 陈则友 陈颖 李林云 祝思源 毛大庆 罗义[1,2] Duan Yujing;Wu Xinyan;Chen Zeyou;Chen Ying;Li Linyun;Zhu Siyuan;Mao Daqing;Luo Yi(Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria,College of Environmental Science and Engineering,Nankai University,Tianjin 300350,China;State Key Laboratory of Pollution Control and Resource Reuse,School of the Environment,Nanjing University,Nanjing 210093,China;School of Medicine,Nankai University,Tianjin 300071,China;College of Environment,Liaoning University,Shenyang 110036,China)

机构地区：[1]南开大学环境科学与工程学院,环境污染过程与基准教育部重点实验室,天津300350 [2]南京大学环境学院,污染控制与资源化国家重点实验室,南京210093 [3]南开大学医学院,天津300071 [4]辽宁大学环境学院,沈阳110036

出　　处：《生态毒理学报》2020年第4期1-10,共10页Asian Journal of Ecotoxicology

基　　金：国家自然科学基金重点资助项目(41831287);国家杰出青年科学基金资助项目(41525013);国家自然科学基金资助项目(31670509,41977367,31870351,41807483);天津市自然科学基金资助项目(19JCZDJC40800)。

摘　　要：人类肠道菌群是耐药基因(antibiotic resistance genes,ARGs)的“储存库”,且与人体健康密切相关。目前,抗生素的滥用严重,进一步加剧了耐药基因的传播和扩散。细菌耐药问题严重影响人体健康、食品安全和生态安全,携带耐药基因的致病菌对临床治疗造成巨大威胁。本文结合国内外研究进展,在总结人体肠道耐药基因组研究方法的基础上,探讨了肠道耐药基因的组成、来源、传播和进化,并对未来研究进行了展望,旨在促进公众对肠道耐药基因的认知,并为抗生素的合理使用提供理论支持。Human gut microbiota is the reservoir of antibiotic resistance genes(ARGs)and it plays an important role to human health.The abuse of antibiotics is still severe at present,which further aggravates the spread of ARGs.Bacterial resistance seriously affects human health,food safety and ecological safety,and pathogens carrying ARGs pose a great threat to clinical treatment.In combination with the research progress in China and abroad,this paper discussed in detail about gut resistome from the aspects including the composition,origin,propagation and evolution.In addition,the research methods of human gut resistome and the future prospect were summarized.This study could promote the public’s understanding of gut resistome and provide theoretical support for rational use of antibiotics.

关 键 词：抗生素 耐药基因 肠道菌群 水平基因转移 

分 类 号：X171.5[环境科学与工程—环境科学]