青光眼滤过性手术抗瘢痕化治疗的研究进展  

Research progress of anti-scar treatment in glaucoma filtering surgery

作　　者：王玲[1,2] 樊芳 贾志旸[1] WANG Ling;FAN Fang;JIA Zhiyang(Hebei General Hospital,Shijiazhuang 050051,Hebei Province,China;North China University of Science and Technology,Tangshan 063210,Hebei Province,China)

机构地区：[1]河北省人民医院,河北省石家庄市050051 [2]华北理工大学,河北省唐山市063210

出　　处：《眼科新进展》2020年第11期1084-1089,1096,共7页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号81700835)。

摘　　要：青光眼滤过性手术(glaucoma filtration surgery,GFS)作为抗青光眼的主要术式在临床上得到了广泛应用,但术后滤过泡的瘢痕化是导致手术失败的主要原因。术中及术后使用抗代谢药物如5-氟尿嘧啶(5-fluorouracil,5-FU)和丝裂霉素C(mitomycin-C,MMC)虽然有一定效果,但其具有威胁视力的严重并发症。为进一步提高GFS的成功率,抗瘢痕化治疗成为近年来的研究热点。本文对近年来青光眼滤过性手术的抗瘢痕化药物及新型材料的研究进行了综述,为临床中寻找抗瘢痕化效率高、不良反应少、安全性好的药物或材料提供了新的思路和方法。Glaucoma filtration surgery(GFS)has been widely used in clinic as a major anti-glaucoma operation,but the scarring of the postoperative filtering bleb is the main reason for the failure of the operation.Intraoperative or postoperative use of antimetabolites such as 5-fluorouracil or mitomycin-c has been shown to be effective.However,it has serious complications that threaten vision.In order to improve the success rate of glaucoma filtration surgery,anti-scar therapy has become a research focus in recent years.This thesis reviews the research on anti-scar drugs and new materials for GFS in recent years,providing new ideas and methods for finding drugs or materials with high anti-scar efficiency,less side effects and good safety in clinic.

关 键 词：青光眼 滤过性手术 瘢痕化 抗瘢痕治疗 

分 类 号：R775[医药卫生—眼科]