安神生化汤联合帕罗西汀片治疗产后抑郁临床研究  

Clinical research of Anshen-Shenghua Decoction combined with paroxetine hydrochloride tablets in treating postpartum depression

作　　者：徐临亚 王祖娴 徐静 眭建 Xu Linya;Wang Zuxian;Xu Jing;Sui Jian(Medical college of Jiangsu University,Zhenjiang 2012013,China)

机构地区：[1]江苏大学医学院,镇江2012013

出　　处：《国际中医中药杂志》2020年第8期750-753,共4页International Journal of Traditional Chinese Medicine

摘　　要：目的评价安神生化汤联合帕罗西汀片治疗产后抑郁的疗效。方法将符合入选标准的2017年9月-2018年11月本院产后抑郁患者82例,按随机数字表法分为2组,每组41例。对照组口服帕罗西汀片,观察组在对照组基础上服用安神生化汤。2组均连续治疗6周。采用汉密顿抑郁量表(Hamilton Depression Scale,HAMD)及爱丁堡产后抑郁量表(edinburgh postpartum depression scale,EPDS)评估患者的抑郁程度,采用ELISA法检测血清超敏C反应蛋白(hypersensitive c-reactive protein,hs-CRP)和同型半胱氨酸(homocysteine,Hcy)水平,评价临床疗效。结果观察组总有效率为97.6%(40/41)、对照组为78.0%(32/41),2组比较差异有统计学意义(χ2=5.581,P=0.018)。观察组治疗后焦虑、昼夜、睡眠障碍、体重、绝望感、认知障碍、阻滞评分均低于对照组(t值分别为12.391、10.941、14.764、12.261、8.446、10.005、8.871,P值均<0.01);EPDS评分均低于对照组(t=7.893,P<0.01)。观察组治疗后血清hs-CRP、Hcy水平均低于对照组(t值分别为8.005、6.553,P<0.01)。结论安神生化汤联合帕罗西汀片可有效缓解产后抑郁患者的抑郁状态,下调血清hs-CRP和Hcy水平。Objective To evaluate the efficacy of Anshen-Shenghua Decoction combined with Paroxetine hydrochloride tablets in treating postpartum depression.Methods Eighty-two postpartum depression patients admitted to our hospital from September of 2017 to November of 2018 were selected and were randomly divided into control group and observation group with 41 cases in each group by random number table methode.The control group received paroxetine hydrochloride tablets.The observation grouptook Anshen-Shenghua Decoction based on the control group.Both of the two groups were treated for 6 weeks.Hamilton Depression Scale(HAMD)factors and Edinburgh Postpartum Depression Scale(EPDS)were used to evaluate the depression degree.The ELISA method was used to detect serum levels of hypersensitive C-reactive protein(hs-CRP)and homocysteine(Hcy).The efficacy was evaluated for both groups.Results The total clinical effective rate of observation group and control group was 97.6%(40/41)and 78.0%(32/41)respectively,with statistically significant difference(χ2=5.581,P=0.018).The scores of anxiety,day and night,sleep disorders,weight,feelings of hopelessness,cognitive impairment,block of the observation group were obviously lower than those of the control group after the treatment(t values were 12.391,10.941,14.764,12.261,8.446,10.005,8.871 respectively,all Ps<0.01).The scores of EPDS in observation group were significantly lower than that of the control group after the treatment(t=7.893,P<0.01).After the treatment,the serum levels of hs-CRP and Hcy in the observation group were significantly lower than those of the control group(t values were 8.005 and 6.553,respectively,all Ps<0.01).Conclusions Anshen-Shenghua Decoction combined with paroxetine hydrochloride tablets in treating postpartum depression can effectively relieve the depression symptoms of postpartum depression patients,and the down-regulation of serum levels of hs-CRP and Hcy.

关 键 词：抑郁症 产后 安神生化汤 C-反应蛋白质 同型半胱氨酸 中西医结合疗法 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R714.6[医药卫生—临床医学]