pSTAT3和PD-L1在结外NK/T细胞淋巴瘤中的表达及意义  

Expression of pSTAT3 and PD-L1 in extranodal NK/T cell lymphoma and its clinical significance

作　　者：张芬[1] 罗东兰[1] 陈玉[1] 严金海 罗陆侨[1] 刘健[1] 刘艳辉[1] Zhang Fen;Luo Donglan;Chen Yu;Yan Jinhai;Luo Luqiao;Liu Jian;Liu Yanhui(Department of Pathology,Guangdong Provincial People′s Hospital/Guangdong Academy of Medical Sciences,Guangzhou 510080,China)

机构地区：[1]广东省人民医院(广东省医学科学院)病理医学部病理科,广州510080

出　　处：《中华病理学杂志》2020年第10期999-1002,共4页Chinese Journal of Pathology

基　　金：国家临床重点专科建设项目;广东省医学科学技术研究基金(B2017022)。

摘　　要：目的探讨结外NK/T细胞淋巴瘤中pSTAT3和PD-L1表达及其与临床病理特征及预后的关系。方法收集广东省人民医院2015年6月至2019年2月51例确诊为结外NK/T细胞淋巴瘤的病例,采用免疫组织化学方法,研究pSTAT3和PD-L1在结外NK/T细胞淋巴瘤的表达情况并进行统计学分析。结果51例结外NK/T细胞淋巴瘤中,男性35例,女性16例,年龄范围为18~85岁,中位年龄47岁;pSTAT3阳性率为68.6%(35/51);PD-L1阳性率为76.5%(39/51);两者表达呈正相关(P=0.033,R=0.322)。pSTAT3及PD-L1表达与各临床参数(包括年龄、性别、发病部位、有无B症状、Ann Arbor分期、乳酸脱氢酶值、外周血EB病毒DNA含量、国际预后指数评分)之间均无相关性(P>0.05)。Kaplan-Meier生存分析显示pSTAT3和PD-L1阳性组预后分别略优于阴性组,但差异无统计学意义(P>0.05)。结论pSTAT3在结外NK/T细胞淋巴瘤中高表达,并且与PD-L1表达具有相关性,为结外NK/T细胞淋巴瘤治疗提供了潜在靶点,并为STAT3靶向药物和免疫检查点抑制药物的联合使用提供了一定的理论依据。Objective To study the expression of phosphates signal transducer and activator of transcription 3(pSTAT3)and programmed death ligand-1(PD-L1)in extranodal NK/T cell lymphomas(ENKTCL)and the relationships of pSTAT3 and PD-L1 expression with the clinicopathological characteristics and prognosis of ENKTCL.Methods Fifty-one cases of ENKTCL diagnosed at Guangdong Provincial People′s Hospital from June 2015 to February 2019 were included in the study.The expression of pSTAT3 and PD-L1 was examined using immunohistochemistry.Results There were 35 males and 16 females,ranging from 18 to 85 years old with a median age of 47 years.The positive rates of pSTAT3 and PD-L1 expression were 68.6%(35/51)and 76.5%(39/51),respectively.pSTAT3 expression was correlated with PD-L1 expression(P=0.033,R=0.322),while there were no associations of pSTAT3 and PD-L1 expression with the clinicopathological characteristics of ENKTCL,including age,sex,clinical site,B symptom,Ann Arbor stage,LDH value,EBV DNA load of peripheral blood and international proliferation index score.Kaplan-Meier survival analysis showed the prognoses of the pSTAT3 and PD-L1 positive groups were slightly better than the respective negative groups,but the differences were not significantly(P>0.05).Conclusions pSTAT3 is highly expressed in extranodal NK/T cell lymphoma and related to the expression of PD-L1,which provides a potential target and rationale for combinations of targeted therapies and immune checkpoint blockade inhibitors in the treatment of ENKTCL.

关 键 词：淋巴瘤 结外NK-T细胞 预后 分子靶向治疗 

分 类 号：R733.1[医药卫生—肿瘤]