临床治愈抑郁症患者脑突显网络功能连接变化的追踪研究  

A follow-up study on the changes in salience network function connectivity in clinically cured patients with depression

作　　者：王珍珍 钟佳琪 马辉[2] 滕昌军 韩洋 王慧 张宁 Wang Zhenzhen;Zhong Jiaqi;Ma Hui;Teng Changjun;Han Yang;Wang Hui;Zhang Ning(School of Psychology,Nanjing Normal University,Nanjing 210097,China;Department of Medical Psychology,Affiliated Nanjing Brain Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京师范大学心理学院,210097 [2]南京医科大学附属脑科医院医学心理科,210029

出　　处：《中华精神科杂志》2020年第5期400-405,共6页Chinese Journal of Psychiatry

基　　金：江苏省重点研发计划(社会发展)项目(BE2015609);南京市医学科技发展重点项目(ZKX10022);南京医科大学科技发展基金(NMUB2018197)。

摘　　要：目的探讨抑郁症患者达临床治愈后突显网络功能连接的变化。方法选取22名健康对照者(对照组)和17例临床治愈抑郁症患者(临床治愈组)进行静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)扫描,抑郁症患者在临床治愈基线期以及治愈6个月时分别进行扫描,对rs-fMRI数据进行常规预处理,利用独立成分分析(independent component analysis,ICA)提取突显网络,采用t检验比较基线期、治愈6个月临床治愈组与对照组的突显网络功能连接差异,并对结果进行AlphaSim校正。结果与对照组相比,基线期临床治愈组背外侧前额叶(t=2.84)功能连接值增高(P<0.01,AlphaSim校正);与基线期相比,治愈6个月的抑郁症患者内侧前额叶(t=4.08)功能连接值增高,而楔前叶(t=-3.06)和背外侧前额叶(t=-2.98)功能连接值减低(P<0.01,AlphaSim校正)。结论抑郁症患者达临床治愈后突显网络功能连接水平在6个月中并不稳定,基线期临床治愈抑郁症患者突显网络仍存在功能连接异常的脑区,而临床治愈6个月未见突显网络功能连接异常脑区。Objective To explore the change of salience network functional connectivity over time in patients with clinically cured depression.Methods Twenty-two healthy controls(control group)and 17 clinically cured depressed patients(clinically cured group)underwent resting-state functional magnetic resonance imaging(rs-fMRI)scan at baseline and 6 months later.Routine preprocessing of rs-fMRI data was performed.Salience network was extracted by independent component analysis(ICA)followed by a t-test to compare the differences of salience network functional connectivity between the control group and clinically cured patient group at both baseline and 6 months follow-up.Results were corrected by AlphaSim correction method.Results At baseline,compared to the control group,clinically cured patient group showed a significantly increased functional connectivity in the dorsolateral prefrontal cortex(t=2.84,P<0.01,AlphaSim correction)and a significantly increased functional connectivity in the medial prefrontal cortex(t=4.08,P<0.01,AlphaSim correction)as well as a decreased functional connectivity in the left precuneus(t=-3.06)and dorsolateral prefrontal cortex(t=-2.98,P<0.01,AlphaSim correction)at 6 months follow-up.Conclusion Patient′s functional connectivity of salience network may not stable during the first 6 months after being clinically cured.The abnormal functional connectivity in the dorsolateral prefrontal cortex when they are initially and clinically cured may gradually improve.

关 键 词：抑郁症 磁共振成像 突显网络 临床治愈 功能连接 

分 类 号：R749.4[医药卫生—神经病学与精神病学]