雷替曲塞或5-氟尿嘧啶/亚叶酸钙联合奥沙利铂化疗治疗老年晚期结直肠癌的疗效比较  

Effect Comparison on Senior Late Colorectal Cancer Treated with Raltitrexed plus Oxaliplatin,and with5-FU,Calcium Folinic Acid plus Oxaliplatin

作　　者：陈月圆 CHEN Yue-yuan(The Central Hospital of Nanyang City,Nanyang,Henan 473000)

机构地区：[1]河南省南阳市中心医院,河南南阳473000

出　　处：《中国肛肠病杂志》2020年第8期8-9,共2页Chinese Journal of Coloproctology

摘　　要：为探讨一种理想的治疗老年晚期结直肠癌的化疗方案,将2017年6月至2018年6月于我院肿瘤科就诊的70例老年晚期结直肠癌患者随机分为观察组和对照组,各35例。观察组予雷替曲塞注射液(3mg/m^2,静脉滴注,d1)联合奥沙利铂(130mg/m^2,静脉滴注,d1)化疗;对照组予5-氟尿嘧啶(5-FU,375mg/m^2,静脉滴注,d1~d5)、亚叶酸钙(LV,200mg/m^2,静脉滴注,d1~d5)、奥沙利铂(130mg/m^2,静脉滴注,d1)化疗。比较2组患者临床治疗总有效率、疾病控制率、不良反应发生情况、疾病进展时间。结果显示,观察组治疗总有效率、疾病控制率均明显高于对照组,P<0.05。2组患者不良反应发生率比较差异无统计学意义,P>0.05;观察组患者疾病进展时间明显长于对照组,P<0.05。结果表明,雷替曲塞联合奥沙利铂化疗治疗老年晚期结直肠癌患者的临床疗效优于5-氟尿嘧啶/亚叶酸钙联合奥沙利铂化疗。This study was to explore an ideal chemotherapy schema for treating senior late colorectal cancer,randomly divided 70cases of this cancer treated in author's hospital(2017-06-2018-06)into observation group[35cases,intravenously injecting raltitrexed(3mg/m^2,d1)and oxaliplatin(130mg/m^2,d1)]and control group[35cases,intravenously injecting 5-FU(375mg/m^2,d1-d5),calcium folinic acid(LV)(200mg/m^2,d1-d5)and oxaliplatin(130mg/m^2,d1)];then,compared both groups'total effective rate,disease control rate(DCR),untoward reaction incidence,and time-to-progression(TTP).As results,in total effective rate and DCR,as well as in TTP,observation group was significantly and respectively higher,as well as longer than control group;in untoward reaction incidence there was no statistical difference between the two groups(P>0.05).Results show that the schema used in observation group is superior to one used in control group in clinical effect.

关 键 词：晚期结直肠癌 老年人 雷替曲塞 5-氟尿嘧啶 奥沙利铂 疗效 

分 类 号：R735.34[医药卫生—肿瘤]