非酒精性脂肪肝并发肝功能损害的危险因素分析  

Risk factors of nonalcoholic fatty liver disease complicated with liver function damage

作　　者：周颖[1] 方林花 林敏[1] ZHOU Ying;FANG Linhua;LIN Min(Affiliated Hangzhou First People's Hospital,Zhejiang University School of Medicine,Hangzhou 310006,China)

机构地区：[1]浙江大学医学院附属杭州市第一人民医院消化内科,浙江杭州310006

出　　处：《全科医学临床与教育》2020年第10期900-903,共4页Clinical Education of General Practice

摘　　要：目的探讨非酒精性脂肪肝并发肝功能损害的相关危险因素。方法回顾性选择220例非酒精性脂肪肝患者,其中并发肝功能损害68例(观察组),未并发肝功能损害152例(对照组),分析比较两组年龄、性别、体重指数(BMI)、高血压、吸烟、饮酒情况及低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FBG)、血尿酸(UA)水平等,并采用logistic多因素回归分析脂肪肝并发肝功能损害的相关危险因素。结果两组在吸烟、慢性饮酒、肥胖、高血压、坚持运动、LDL-C、FBG及UA、HDL-C水平等方面比较,差异具有统计学意义(χ^2分别=5.61、8.05、12.02、6.95、10.15,t分别=27.82、3.94、9.62、3.01,P均<0.05),logistic分析结果显示,肥胖、慢性饮酒、高血压、吸烟、UA升高、FBG升高和LDL-C升高是非酒精性脂肪肝合并肝功能损害的危险因素(OR分别=5.50、5.07、3.87、2.69、1.57、1.61、1.73,P均<0.05),HDL-C升高、坚持运动锻炼是非酒精性脂肪肝合并肝功能损害的保护因素(OR分别=0.04、0.14,P均<0.05)。结论吸烟、慢性饮酒、肥胖、高血压及LDL-C、FBG、UA水平升高与非酒精性脂肪肝并发肝功能损害的发生密切相关,合理饮食、坚持运动锻炼可降低非酒精性脂肪肝并发肝功能损害的风险。Objective To explore the risk factors of non-alcoholic fatty liver complicated with liver function damage.Methods The clinical data of 220 patients with nonalcoholic fatty liver was analyzed retrospectively.Totally 68 patients with fatty liver complicated with liver function damage were included in the observation group and 152 patients without liver function damage were included in the control group.The age,gender,body mass index(BMI),hypertension,smoking,drinking,LDL-C,HDL-C,FBG,and UA levels were compared between the two groups.Logistic regression analysis was used to analyze the risk factors of fatty liver complicated with liver function damage.Results There were statistically significant differences in smoking,chronic drinking,obesity,hypertension,daily exercise,LDL-C,fasting blood glucose,blood uric acid,and HDL-C between two groups(χ^2=5.61,8.05,12.02,6.95,10.15,t=27.82,3.94,9.62,3.01,P<0.05).The results of logistic analysis showed that obesity,chronic drinking,hypertension,smoking,high levels of UA,FBG and LDL-C were the risk factors of nonalcoholic fatty liver combined with liver function damage(OR=5.50,5.07,3.87,2.69,1.57,1.61,1.73,P<0.05).High level of HDL-C and daily exercise were the protective factors of nonalcoholic fatty liver combined with liver function damage(OR=0.04,0.14,P<0.05).Conclusion Drinking,smoking,obesity,hypertension,high levels of LDL-C,FBG,and UA are obviously related to the occurrence of nonalcoholic fatty liver combined with liver function damage.Reasonable diet and exercise can reduce the risk of nonalcoholic fatty liver combined with liver function damage.

关 键 词：非酒精性脂肪肝 肝功能损害 危险因素 

分 类 号：R575.5[医药卫生—消化系统]