TLRs/IRAK1/TRAF6/NF-κB信号通路介导神经炎症参与神经病理性痛的研究进展  

The research progress on TLRs/IRAK1/TRAF6/NF-κB signaling pathway mediating neuroinflammation in neuropathic pain

作　　者：王新颖 任安 李梦绮 夏阳阳 黄诚[2,3] WANG Xin-ying;REN An;LI Meng-qi;XIA Yang-yang;HUANG Cheng(Gannan Medical University;School of Basic Medicine of Gannan Medical University;Institute of Pain Medicine,Gannan Medical University,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医学院 [2]赣南医学院基础医学院 [3]赣南医学院疼痛医学研究所,江西赣州341000

出　　处：《赣南医学院学报》2020年第9期917-923,共7页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：国家自然科学基金项目(31160213);赣鄱英才555工程领军人才项目;江西省主要学科学术和技术带头人培养计划项目(20142BCBC22008)。

摘　　要：TLRs/IRAK1/TRAF6/NF-κB信号通路参与炎症形成和免疫应答,并且其介导的神经炎症在神经病理性痛的发生发展中起着至关重要的作用,这将为药物干预神经病理性痛提供新的治疗靶点。为此,本文就TLRs/IRAK1/TRAF6/NF-κB信号通路介导的神经炎症参与神经病理性痛的研究进展进行综述,为临床治疗神经病理性痛提供依据。TLRs/IRAK1/TRAF6/NF-κB signaling pathway is involved in the formation of inflammation and immune response.The neuroinflammation mediated by it plays a vital role in the occurrence and development of neuropathic pain,which may provide new therapeutic targets for drug treatment of neuropathic pain.This review summarizes the research progress of neuroinflammation participated in neuropathic pain mediated by TLRs/IRAK1/TRAF6/NF-κB signaling pathway,and provides a basis for clinical treatment of neuropathic pain.

关 键 词：神经病理性痛 TLRS IRAK1/TRAF6 NF-ΚB 神经炎症 

分 类 号：R338[医药卫生—人体生理学]