Association of interleukin-18 gene polymorphisms with Takayasu arteritis in a Chinese Han population  

作　　者：Dan Wen Xian-Liang Zhou Xin Du Jian-Zeng Dong Chang-Sheng Ma 

机构地区：[1]Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University,National Clinical Research Center for Cardiovascular Diseases,Beijing Advanced Innovation Center for Big Data-Based Precision Medicine for Cardiovascular Diseases,Beijing 100029,China [2]Department of Cardiology,Fuwai Hospital,National Center for Cardiovascular Disease,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100037,China.

出　　处：《Chinese Medical Journal》2020年第19期2315-2320,共6页中华医学杂志（英文版）

基　　金：grants from the National Key Research and Development Program of China(No.2016YFC1301002 and No.2020YFC2004803);National Natural Science Foundation of China Grant(No.81900449).

摘　　要：Background:Interleukin-18(IL18)gene polymorphisms are related to many inflammatory and autoimmune diseases.However,a correlation analysis between IL18-607C/A and-137G/C gene polymorphisms and Takayasu arteritis(TA)is lacking.Methods:This study enrolled 200 patients with TA as the case group and 334 region-,age-,and sex-matched healthy subjects as the control group.We genotyped alleles and genotypes at positions-607 and-137 of the IL18 gene and analyzed the distribution frequencies.Mann-Whitney U test,t test,Chi-squared test and Hardy-Weinberg equilibrium were performed.Results:After adjusting for risk factors,the adjusted odds ratios and 95%confidence intervals at position-607C/A were 0.533,0.391 to 0.880(P=0.010);0.266,0.586 to 1.002(P=0.051);and 0.122,0.552 to 1.420(P=0.613)under the dominant,additive,and recessive models,respectively.For the-137G/C polymorphism,the adjusted odds ratios and 95%confidence intervals were 1.571,1.068 to 2.311(P=0.022);1.467,1.086 to 1.980(P=0.012);and 1.815,0.901 to 3.656(P=0.095)under the dominant,additive,and recessive models,respectively.Moreover,regardless of the model used,we found no statistical difference in distribution frequency between the active and quiescent states of TA for the-607C/A(P=0.355,0.631,and 0.705,respectively)and-137G/C polymorphisms(P=0.205,0.385,and 0.208,respectively).Conclusions:The IL18-607C/A gene polymorphism may decrease the risk of TA,and thus is a protective factor,whereas-137G/C may increase the risk of TA,and thus is a risk factor.However,neither polymorphism was related to activity(active vs.quiescent)of TA.

关 键 词：Gene polymorphism INTERLEUKIN-18 Takayasu arteritis 

分 类 号：R543.5[医药卫生—心血管疾病]