How neural stem cells promote the repair of brain injury through immunoregulation  

作　　者：Cheng Jiang Bo-Ru Hou Ze-Ning Wang Yi Chen Dong Wang Hai-Jun Ren 

机构地区：[1]Department of Neurosurgery,Lanzhou University Second Hospital,Lanzhou,Gansu 730000,China.

出　　处：《Chinese Medical Journal》2020年第19期2365-2367,共3页中华医学杂志（英文版）

基　　金：grants from the Lanzhou Science and Technology Bureau Project(No.2018-4-68);Lanzhou Science and Technology Plan Project(No.2018SHFZ0062);Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital(No.CY2018-MS08).

摘　　要：Brain injury,such as traumatic brain injury and stroke,are important causes of death and long-term disability all over the world.[1]Inflammation may play an essential role in secondary injury after brain injury.Neural stem cells(NSCs)are pluripotent cells with self-renewal ability.It is initially assumed that NSCs transplantation promotes tissue restoration by direct structural cell replacement.However,the view has been recalibrated over the past decade.Bystander effect providing immunomodulatory,neurotrophic,and reparative support may play a major role instead.[2]However,the specific action mode of NSCs to exert immunomodulatory effect is still a lack of knowledge.On the one hand,the secretion of CD200,CX3 chemokine ligand 1(CX3CL1),NSC-derived exosomes(NSC-Exos),and the regulation of nucleotide oligomerization domain(NOD)-like receptor protein 3(NLRP3)can inhibit the inflammatory effects of microglia.On the other hand,changes in the systemic immune response also function in the immunomodulatory process.This article will focus on these aspects to discuss the potential immunoregulation mechanisms of NSCs.

关 键 词：INJURY MODULATOR NEURAL 

分 类 号：R651.15[医药卫生—外科学] R743.3[医药卫生—临床医学]