炎症与急性缺血性脑卒中出血转化研究进展  

Research progress of update on inflammation and hemorrhagic transformation

作　　者：何明月 陆菁菁[1] He Mingyue;Lu Jingjing(Department of Neurology,Beijing Tiantan Hospital Affiliated to Capital Medical University,Beijing 100070,China)

机构地区：[1]首都医科大学附属北京天坛医院神经内科,100070

出　　处：《中华神经科杂志》2020年第9期732-735,共4页Chinese Journal of Neurology

基　　金：国家重点研发计划-重大慢性非传染性疾病防控研究(2018YFC1312200)。

摘　　要：急性缺血性脑卒中是最常见的脑卒中类型。出血转化是其严重并发症之一,会加重神经功能恶化,导致不良预后。出血转化的发生与高龄、大面积梗死、糖尿病、心源性栓塞等多种危险因素相关。近年来多项研究结果提示了炎症与出血转化之间的显著相关性。在急性缺血-再灌注损伤模型中,发现了多种炎性细胞的聚集与激活,释放炎性因子,破坏血脑屏障,导致出血转化的发生。本文旨在探究炎症在出血转化风险预测和临床预后中的作用。Acute ischemic stroke is the most common type of stroke.Hemorrhagic transformation is one of the serious complications of acute ischemic stroke,which can aggravate the deterioration of neural system function and adverse prognosis.Several studies have shown that the occurrence of hemorrhagic transformation after acute ischemic stroke is associated with risk factors such as old age,massive infarction,diabetes mellitus and cardiogenic embolism.In recent years,many studies have confirmed that there is a significant correlation between inflammation and hemorrhagic transformation in acute ischemic stroke.Inflammatory cells were activated and aggregated in the blood vessel and brain parenchyma of acute ischemia-reperfusion injury,which released many inflammatory factors,caused the destruction of blood-brain barrier and hemorrhagic transformation.This review aims to explore the role of inflammation in the risk of hemorrhagic transformation and clinical prognosis in acute ischemic stroke.

关 键 词：卒中 脑出血 炎症 中性粒细胞 淋巴细胞 小胶质细胞 

分 类 号：R743.3[医药卫生—神经病学与精神病学]