人血清脂蛋白相关磷脂酶A2与血糖、血脂的相关性研究  

Study on the correlation between human serum lipoprotein related phospholipase A2 and blood glucose and lipid

作　　者：杨平[1] 方堃[1] 井婧[1] YANG Ping;FANG Kun;JING Jing(Department of Clinical Laboratory,Sichuan Science City Hospital,Mianyang,Sichuan 621900,China)

机构地区：[1]四川省科学城医院检验科,四川绵阳621900

出　　处：《国际检验医学杂志》2020年第21期2620-2623,共4页International Journal of Laboratory Medicine

基　　金：四川省卫生和计划生育委员会科研课题(18PJ385)。

摘　　要：目的对脂蛋白相关磷脂酶A2(LP-PLA2)与年龄、血糖(GLU)、糖化血红蛋白、胆固醇、三酰甘油(TG)和低密度脂蛋白胆固醇的相关性进行研究,探讨健康人群LP-PLA2参考区间的建立,以及与心脑血管传统指标的相关性。方法选取2018年4-10月在该院健康管理部进行健康体检人群共2836例作为研究对象,采集空腹静脉血进行相关指标测定。依据GLU水平不同分为GLU正常组(<6.1 mmol/L)、GLU受损组(6.1~6.9 mmol/L)、GLU增高组(>6.9 mmol/L);依据TG水平不同分为正常组(<1.70 mmol/L)、轻度危害组(1.70~2.83 mmol/L)、中重度危害组(>2.83 mmol/L)。结果LP-PLA2在部分年龄段存在明显差异;在排除年龄因素的影响因素后,GLU与LP-PLA2无明显相关性(P>0.05);LP-PLA2在TG不同水平组(正常组、轻度危害组、中重度危害组)之间存在明显差异(P<0.05),并且随TG水平增高呈下降趋势。结论应制订适合该地区不同年龄段LP-PLA2的参考区间,以便更好地应用于临床;在健康人群中,GLU水平不会影响体内LP-PLA2水平;高血脂可能会抑制血液中LP-PLA2的表达水平。Objective To study the relationship between lipoprotein associated phospholipase A2(LP-PLA2)and age,blood glucose(GLU),glycosylated hemoglobin,cholesterol,triglyceride(TG)and low-density lipoprotein cholesterol,and to explore the establishment of reference interval of LP-PLA2 in healthy population and its correlation with the traditional indexes of cardiovascular vessels.Methods A total of 2836 people were selected from health examination population in the Ministry of Health Management of the hospital from April to October in 2018.According to the different levels of GLU,they are divided into normal GLU group(<6.1 mmol/L),impaired GLU group(6.1-6.9 mmol/L),increased GLU group(>7.0 mmol/L).According to the different levels of TG,they are divided into normal groups(<1.70 mmol/L),mild-hazard group(1.70-2.83 mmol/L),moderate and severe-hazard group(>2.83 mmol/L).Results LP-PLA2 had obvious differences between some age groups.GLU has no correlation with LP-PLA2 after excluding the factors of age(P>0.05).LP-PLA2 showed significant differences between groups with different TG levels(normal group,mild-hazard group,moderate and severe-hazard group)(P<0.05),and with the increase of TG level,LP-PLA2 level had a declining trend.Conclusion The reference range of LP-PLA2 at different ages should be established in this area for better clinical application.GLU levels in healthy people did not affect LP-PLA2 levels in the body.High blood lipids could inhibit the expression of LP-PLA2.

关 键 词：脂蛋白相关磷脂酶A2 血脂 血糖 年龄因素 参考值 

分 类 号：R743.33[医药卫生—神经病学与精神病学]