持续气道正压通气治疗对OSAHS患者肠道菌群的影响  

Effect of Continuous Positive Airway Pressure on Intestinal Flora in Patients with OSAHS

作　　者：黎燕群[1] 万程伟[1] 陈妍 张敏[1] 刘辉玉 LI Yanqun;WAN Chengwei;CHEN Yan;ZHANG Min;LIU Huiyu(Ganzhou People’s Hospital,Ganzhou 341000,China;不详)

机构地区：[1]赣州市人民医院,江西赣州341000

出　　处：《现代医院》2020年第10期1539-1541,共3页Modern Hospitals

基　　金：江西省卫生健康委员会科技计划项目(20204554)。

摘　　要：目的探究持续气道正压通气(coutinuous positive airway pressure,CPAP)治疗对阻塞性睡眠呼吸暂停低通气综合征(阻塞性睡眠呼吸暂停低通气综合征obstructive sleep apnea hypopnea syndrome,OSAHS)患者肠道菌群的影响。方法于2018年5月—2019年10月在我院选取确诊为OSAHS的患者41例为观察组和同期健康体检者41例为对照组。观察组行CPAP治疗,并于治疗前后对两组进行肠道菌群测定和三甲胺氮氧化物(trimethylamine oxide,TMAO)含量测定,观察两组肠道菌群水平、治疗前后观察组肠道菌群香农多样性指数、菌群总丰度以及TMAO水平。结果观察组肠道内产气荚膜梭菌数量较对照组多,而乳酸杆菌、肠球菌、双歧杆菌数量较对照组少,差异有统计学意义(P <0.05);治疗后观察组肠道菌群香农多样性指数较治疗前减少、菌群总丰度较治疗前增加,TMAO水平较治疗前降低,差异有统计学意义(P<0.05)。结论肠道菌群在OSAHS患者中起着重要的作用,CPAP治疗能纠正OSAHS患者的肠道菌群紊乱,降低心脑血管并发症发生率,对OSAHS治疗效果好。Objective To explore the effect of continuous positive airway pressure( CPAP) therapy on intestinal flora in patients with obstructive sleep apnea hypopnea syndrome( OSAHS) Methods From May 2018 to October 2019,41 patients in our hospital diagnosed with OSAHS were selected as the observation group and 41 healthy people selected as the control group. The treatment group received CPAP treatment,and the intestinal flora of the two groups was measured before and after treatment;and trimethylamine N-oxide( trimethylamine oxide,TMAO),the level of the intestinal flora were measured before and after treatment;and intestinal bacteria Shannon diversity index group,the total abundance of flora and TMAO levels of the two groups were observed. Results The number of intestinal perfringens in the observation group was larger than in the control group;Lactobacillus,Enterococcus,Bifidobacterium was less than the control group;and the differences were statistically significant( P < 0. 05);after treatment,flora Shannon diversity index in the observation group was lower than before treatment,the total abundance of flora was higher than before treatment,and TMAO levels were lower than before treatment;the difference was statistically significant( P < 0. 05). Conclusion The intestinal flora plays an important role in OSAHS patients,CPAP treatment can correct disorders of intestinal flora in OSAHS patients and reduce the incidence of cardiovascular complications,and thus has good curative effect on OSAHS.

关 键 词：CPAP OSAHS 肠道菌群 TMAO 

分 类 号：R574[医药卫生—消化系统]