阿尔茨海默病的脑血流灌注成像研究进展  

Advances in cerebral perfusion imaging of Alzheimer's disease

作　　者：王子含 闫少珍(综述) 卢洁(审校)[1,2,3] WANG Zihan;YAN Shaozhen;LU Jie(Department of Radiology,Xuanwu Hospital,Capital Medical University,Beijing 100053,P.R.China;Department of Nuclear Medicine,Xuanwu Hospital,Capital Medical University,Beijing 100053,P.R.China;Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics,Beijing 100053,P.R.China)

机构地区：[1]首都医科大学宣武医院放射科,北京100053 [2]首都医科大学宣武医院核医学科,北京100053 [3]磁共振成像脑信息学北京市重点实验室,北京100053

出　　处：《医学影像学杂志》2020年第10期1929-1931,1935,共4页Journal of Medical Imaging

基　　金：国家重点研发项目(编号:2016YFC0103909);北京市医院管理局“登峰”项目(编号:DFL20180802)。

摘　　要：阿尔茨海默病(Alzheimer's disease,AD)是老年痴呆最常见的一种类型,2/3的AD患者由轻度认知功能障碍(mild cognitive impairment,MCI)转变而来。AD起病原因复杂,约有1/3由脑血管危险因素所致。脑灌注成像技术主要包括单光子发射计算机断层显像(single photon emission computed tomography,SPECT)、正电子发射断层显像(positron emission tomography,PET)以及磁共振血流灌注成像等,通过对脑组织灌注情况进行定量分析,对于AD的诊断、严重程度评估及预后进展等研究具有重要价值。本文就脑灌注成像技术在AD的研究进展进行综述。Alzheimer's disease(AD)is the most common form of dementia,with two-thirds of patients suffering from mild cognitive impairment(MCI).The causes of AD are complex.About 1/3 of AD are caused by cerebrovascular risk factors.Cerebral perfusion imaging techniques mainly include single photon emission computed tomography,positron emission tomography and magnetic resonance perfusion imaging.Through quantitative analysis of brain tissue perfusion,it is of great value for the diagnosis,severity assessment and prognosis progress of AD.This paper reviews the application of cerebral perfusion imaging in AD.

关 键 词：阿尔茨海默病 脑灌注成像 单光子发射计算机断层显像 正电子发射断层显像 

分 类 号：R742[医药卫生—神经病学与精神病学] R445[医药卫生—临床医学]