周细胞在缺血性脑卒中的作用机制进展  

Progress in the mechanism of pericytes in ischemic stroke

作　　者：彭拥军 李文倩 吕鹤群 徐疏影 吴旭 朱冰梅 PENG Yongjun;LI Wenqian;LYU Hequn;XU Shuying;WU Xu;ZHU Bingmei(Department of Acupuncture and Rehabilitation,Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Province,Nanjing210029,China;Department of Acupuncture,Yancheng Hospital of Traditional Chinese Medicine,Jiangsu Province,Yancheng224001,China;Centre for Regenerative Medicine,West China Hospital of Sichuan University,Sichuan Province,Chengdu610041,China)

机构地区：[1]南京中医药大学附属医院针灸康复科,江苏南京210029 [2]江苏省盐城市中医院针灸科,江苏盐城224001 [3]四川大学华西医院再生医学中心,四川成都610041

出　　处：《中国医药导报》2020年第29期29-32,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81973932、81574060、81001556);中国博士后科学基金项目(2015M571790);全国老中医药专家学术经验继承人项目(国中医药人教发〔2017〕29号)。

摘　　要：脑周细胞是神经血管单元的重要组成部分,近年来关于脑缺血的研究重点逐渐从神经元转移到神经血管单元。周细胞位于神经血管单元的中心,近年来成为新兴研究领域中的焦点。脑周细胞通过整合、处理邻近细胞的信号产生反应,发挥多种功能,包括调节血脑屏障、调节脑血流、调节免疫炎症反应、参与血管生成、调控干细胞活性以及表观遗传调控等。本文通过检索近年来国内外相关文献,探讨周细胞在缺血性脑卒中的功能和作用机制,为缺血性脑卒中机制研究提供参考,为发现新的治疗靶点提供思路。Cerebral pericytes are an important part of neurovascular units.In recent years,the focus of research on cerebral ischemia has gradually shifted from neurons to neurovascular units.Pericytes are located in the center of neurovascular units and have become the focus of new research fields in recent years.Pericerebral cells perform a variety of functions by integrating and processing the signals of neighboring cells,including regulating the blood-brain barrier,regulating cerebral blood flow,regulating immune inflammatory response,participating in angiogenesis,regulating stem cell activity and epigenetic regulation.By reviewing the relevant literature at home and abroad in recent years,this paper discusses the function and mechanism of pericytes in ischemic stroke,so as to provide reference for the study of the mechanism of ischemic stroke and provide ideas for the discovery of new therapeutic targets.

关 键 词：缺血性脑卒中 周细胞 神经血管单元 血脑屏障 

分 类 号：R743.3[医药卫生—神经病学与精神病学]