急性脑梗死患者血清学指标与神经功能缺损和脑梗死体积及颈动脉斑块性质的相关性研究  

Correlation of hs-C R P,MMP-9 and Lp-PLA2 with neurological deficit,cerebral infarction volume and carotid plaque properties in patients with acute cerebral infarction

作　　者：郝泽林 吴建跃[1] 滕振飞 黄智慧 程军[1] HAO Ze-lin;WU Jian-yue;TENG Zhen-fei;HUANG Zhi-hui;CHENG Jun(Department of Neurosurgery,the Affiliated Hospital of Hangzhou Normal University,Hangzhou,Zhejiang 310015,China;不详)

机构地区：[1]杭州师范大学附属医院神经外科,浙江杭州310015 [2]杭州师范大学药学院,浙江杭州310000

出　　处：《中华全科医学》2020年第11期1803-1806,共4页Chinese Journal of General Practice

基　　金：国家自然科学基金面上项目(31671071);杭州市科技计划引导项目(20163501Y11)。

摘　　要：目的探讨急性脑梗死(ACI)患者超敏C-反应蛋白(hs-CRP)、基质金属蛋白酶-9(MMP-9)及脂蛋白相关磷脂酶-A2(Lp-PLA2)与神经功能缺损、脑梗死体积及颈动脉斑块性质的相关性。方法选择2017年6月-2020年2月在杭州师范大学附属医院收治的ACI患者120例(ACI组),另选取同期体检健康人群60例(健康对照组)。比较不同分组hs-CRP、MMP-9及Lp-PLA2水平变化,Spearman法分析相关性。结果 ACI组hs-CRP、MMP-9及Lp-PLA2水平明显高于健康对照组(t=20.364、22.115、14.163,均P<0.05);轻、中、重度神经功能缺损组hs-CRP、MMP-9及Lp-PLA2水平依次升高,差异显著(F=171.283、82.137、278.610,均P<0.05);小、中、重梗死灶组hs-CRP、MMP-9及Lp-PLA2水平依次升高,差异显著(F=100.672、59.707、134.199,均P<0.05);无、稳定、不稳定斑块组hs-CRP、MMP-9及Lp-PLA2水平依次升高,差异显著(F=50.120、34.056、67.255,均P<0.05)。ACI患者MMP-9、hs-CRP及Lp-PLA2水平与神经功能缺损、脑梗死体积、颈动脉斑块性质均呈正相关(均P<0.05)。结论斑块性质越不稳定、脑梗死体积越大、神经功能缺损程度越高,ACI患者血清hs-CRP、MMP-9及Lp-PLA2水平越高。Objective To investigate the correlation of plasma High-sensitivity C-reactive protein(hs-CRP), matrix metalloproteinase-9(MMP-9) and lipoprotein-related phospholipase A2(Lp-PLA2) levels with neurological impairment, cerebral infarction volume and carotid artery plaque stability in patients with acute cerebral infarction(ACI). Methods A total of 120 ACI in patients(ACI group) who were admitted in the Affiliated Hospital of Hangzhou Normal University from June 2017 to February 2020 were selected, and 60 healthy people for physical examination during the same period were selected as health control group. The levels of hs-CRP, MMP-9 and Lp-PLA2 in different groups were compared, and the Spearman Method was used to analyze the correlation. Results The levels of hs-CRP, MMP-9 and Lp-PLA2 in the ACI group were significantly higher than those in the healthy control group(t=20.364, 22.115, 14.163, all P<0.05);the levels of hs-CRP, MMP-9 and Lp-PLA2 in the mild, moderate, and severe neurological deficit groups increased sequentially, with significant differences(F=171.283, 82.137, 278.610, all P<0.05);the levels of hs-CRP, MMP-9 and Lp-PLA2 in the small, moderate, and severe infarct focus group increased sequentially, with significant differences(F=100.672, 59.707, 134.199, all P<0.05);the levels of hs-CRP, MMP-9 and Lp-PLA2 in the non-, stable, and unstable plaque groups increased sequentially, with significant differences(F=50.120, 34.056, 67.255, all P<0.05). The levels of MMP-9, hs-CRP and Lp-PLA2 in ACI patients were positively correlated with neurological deficits, cerebral infarction volume, and carotid plaque Carotid stability(all P<0.05). Conclusion The more unstable the plaque nature, the larger the cerebral infarction volume and the higher the neurological function defect degree were, the higher the serum HS-CRP, MMP-9 and LP-PLA2 levels were.

关 键 词：急性脑梗死 超敏C-反应蛋白 基质金属蛋白酶-9 脂蛋白相关磷脂酶A2 神经功能缺损 脑梗死体积 

分 类 号：R743.3[医药卫生—神经病学与精神病学]