自拟补气养血汤对乳腺癌术后(气血两虚证)化疗患者的辅助治疗作用观察  

Adjuvant Therapeutic Effect of Self-made Buqi Yangxue Decoction for Postoperative Patients with Breast Cancer(Syndrome of Qi-blood Deficiency)

作　　者：徐珩[1] 曾永蕾[1] 周先阳[1] 冷玉玲[1] 吴勇[1] 夏克春[1] 郝婉蓉 XU Heng;ZENG Yonglei;ZHOU Xianyang(Department of Oncology,the Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei Anhui 230001,China)

机构地区：[1]安徽中医药大学第二附属医院肿瘤科,安徽合肥230001

出　　处：《四川中医》2020年第10期168-171,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察自拟补气养血汤对乳腺癌术后(气血两虚证)化疗患者的辅助治疗作用。方法:选取2016年7月~2017年6月医院收治的82例乳腺癌术后(气血两虚证)患者,采用随机数表法将其分为中西医组和西医组,各41例。西医组给予单纯化疗,中西医组在化疗基础上给予自拟补气养血汤治疗,均连用6个周期。评估并对比2组治疗前后中医证候积分;检测并对比治疗前后外周血T淋巴细胞亚群变化情况(CD3^+、CD4^+、CD8^+及CD4^+/CD8^+);评估2组治疗期间发生恶心、呕吐、脱发、骨髓抑制化疗毒副反应程度;随访1年统计复发和死亡情况。结果:中西医组与西医组比,治疗前中医证候积分差异无统计学意义(P>0.05),治疗后中西医组较低(P<0.05);治疗后与治疗前比,2组中医证候积分均降低(P<0.05)。中西医组与西医组相比,治疗前CD3^+、CD4^+、CD8^+及CD4^+/CD8^+差异无统计学意义(P>0.05),而治疗后中西医组CD3^+、CD4^+及CD4^+/CD8^+均较低,CD8^+较高(P<0.05);治疗后与治疗前相比,中西医组CD3^+、CD4^+、CD8^+及CD4^+/CD8^+均无显著变化(P>0.05),而西医组CD3^+、CD4^+及CD4^+/CD8^+均降低,CD8^+升高(P<0.05)。所有患者均有恶心、呕吐、脱发、骨髓抑制现象,中西医组与西医组恶心、呕吐、骨髓抑制等级分布比较,差异均有统计学意义(P<0.05),且中西医组与西医组相比,恶心Ⅲ级发生率、脱发Ⅱ级发生率、呕吐和骨髓抑制Ⅲ+Ⅳ级发生率均较低(P<0.05)。2组复发率和死亡率比较,差异均无统计学意义(P<0.05)。结论:自拟补气养血汤有助于改善乳腺癌(气血两虚证)症状,并且有助于改善化疗免疫抑制作用,降低化疗毒副反应。Objective:To explore the adjuvant therapeutic effect of Self-made Buqi Yangxue Decoction for postoperative patients with breast cancer(syndrome of Qi-blood deficiency).Methods:82 patients with breast cancer after operation(syndrome of Qi-blood deficiency)were selected from July 2016 to June 2017.They were divided into 2 groups by the random number table,41 cases in each group.The western medicine group was treated with Chemotherapy alone,and the western medicine group was treated with Self-made Buqi Yangxue Decoction on the basis of chemotherapy for 6 cycles.The scores of TCM syndromes before and after treatment in two groups were evaluated and compared.The changes of T lymphocyte subsets(CD3^+,CD4^+,CD8^+,CD4^+/CD8^+)in peripheral blood were detected and compared before and after treatment.The degree of side effects of nausea,vomiting,alopecia and bone marrow suppression chemotherapy during treatment were evaluated.Recurrence and death during the 1-year follow-up period were counted.Results:Compared with the western medicine group,there was no significant difference in the scores of TCM syndromes before treatment(P>0.05),but after treatment,the scores of TCM syndromes in the western medicine group were lower(P<0.05).After treatment,the scores of TCM syndromes in both groups were lower than those before treatment(P<0.05).Compared with the western medicine group,there was no significant difference in CD3^+,CD4^+,CD8^+and CD4^+/CD8^+before treatment(P>0.05),but after treatment,CD3^+,CD4^+and CD4^+/CD8^+in the Chinese and western medicine group were lower and CD8^+was higher(P<0.05).Compared with before treatment,there were no significant changes in CD3^+,CD4^+,CD8^+and CD4^+/CD8^+in the group of the traditional Chinese and western medicine after treatment(P>0.05),while CD3^+,CD4^+and CD4^+/CD8^+in the western medicine group decreased,and CD8^+increased treatment(P<0.05).All patients had nausea,vomiting,alopecia and bone marrow suppression,and there were significant differences in the distribution of nausea,vomiting

关 键 词：自拟补气养血汤 乳腺癌 气血两虚证 化疗 免疫功能 

分 类 号：R737.9[医药卫生—肿瘤]