巨泌乳素检测在女性住院精神分裂症患者中的意义  

Significance of macroprolactin detection in the female inpatients with schizophrenia

作　　者：陈海支[1] 费小聪[1] 王振华[1] 沈晔[2] 雷礼磊 赵徐东 曾雷 任丽华[1] CHEN Haizhi;FEI Xiaocong;WANG Zhenhua;SHEN Ye;LEI Lilei;ZHAO Xudong;ZENG Lei;REN Lihua(Department of Psychiatry,the Third People's Hospital of Huzhou City,Zhejiang Province,Huzhou313000,China;Clinical Laboratory,the Third People's Hospital of Huzhou City,Zhejiang Province,Huzhou313000,China)

机构地区：[1]湖州市第三人民医院精神科,浙江湖州313000 [2]湖州市第三人民医院检验科,浙江湖州313000

出　　处：《中国医药导报》2020年第28期105-108,共4页China Medical Herald

基　　金：浙江省医药卫生科技项目面上项目(2018KY786);浙江省湖州市科技局一般计划项目(2017GYB05)。

摘　　要：目的探讨巨泌乳素(MPRL)检测在女性住院精神分裂症患者中的意义。方法收集2018年1月-2019年6月浙江省湖州市第三人民医院精神科住院的65例精神分裂症患者,常规使用利培酮片治疗。在治疗过程中记录患者月经情况,并于治疗前、治疗后第6周末分别用发光免疫分析与酶联免疫吸附测定法检测泌乳素(PRL)和MPRL含量。应用前后自身对照研究对治疗前后PRL及MPRL含量进行比较,同时根据第6周末PRL及MPRL含量将65例患者划分为PRL正常组16例、高PRL血症组49例,将高PRL血症组再分为MPRL血症组21例、非MPRL血症组28例,并对不同组月经延迟情况进行比较。结果65例患者治疗后PRL及MPRL水平较治疗前明显升高,差异均有高度统计学意义(均P<0.01)。PRL正常组、高PRL血症组、MPRL血症组及非MPRL血症组出现的月经延迟数及发生率分别是2例(12.5%)、30例(61.2%)、5例(23.8%)及25例(89.3%)。四组月经延迟发生率两两比较,MPRL血症组与PRL正常组比较,差异无统计学意义(P>0.05),非MPRL血症组月经延迟发生率分别高于高PRL血症组、MPRL血症组及PRL正常组,差异有高度统计学意义(均P<0.01),高PRL血症组月经延迟发生率高于MPRL血症组及PRL正常组,差异有高度统计学意义(均P<0.01)。结论利培酮所致MPRL血症可能不会导致患者月经延迟,临床上检测MPRL有利于指导高PRL血症的治疗。Objective To explore the significance of macroprolactin(MPRL)detection in the female inpatients with schizophrenia.Methods From January 2018 to June 2019,65 schizophrenics patients were collected in Department of Psychiatry,the Third People's Hospital of Huzhou City,Zhejiang Province and all of them were treated with Risperidone Tablets.The menstrual situation of the patients was recorded during the treatment,and the contents of prolactin(PRL)and MPRL were measured by luminescent immunoassay and enzyme-linked immunosorbent assay respectively before and at the end of the sixth weekend of the treatment.The content of PRL and MPRL were compared by self-control study before and after the treatment,at the same time,according to the content of PRL and MPRL at the end of the sixth weekend,65 patients were divided into the normal PRL group(16 cases)and the hyperprolactinemia group(49 cases).The hyperprolactinemia group was then divided into the macroprolactinemia group(21 cases)and the non-macroprolactinemia group(28 cases),and the menstrual delay in different groups was compared.Results The levels of PRL and MPRL in 65 patients after treatment were significantly increased compared with those before treatment,and the differences were highly statistically significant(all P<0.01).The number and incidence of menstrual delay of the normal PRL group,the hyperprolactinemia group,the macroprolactinemia group and the non-macroprolactinemia group were 2 cases(12.5%),30 cases(61.2%),5 cases(23.8%)and 25 cases(89.3%),respectively.The incidence of menstrual delay in four groups was compared in pairs,there was no significant difference between the macroprolactinemia group and the normal PRL group(P>0.05),the incidence of menstrual delay in the non-macroprolactinemia group was higher than that in the hyperprolactinemia group,the macroprolactinemia group and the normal PRL group,with highly statistically significant differences(all P<0.01).The incidence of menstrual delay in the hyperprolactinemia group was higher than that in the macr

关 键 词：利培酮 精神分裂症 泌乳素 巨泌乳素 月经延迟 

分 类 号：R749.3[医药卫生—神经病学与精神病学]