基于中西医临床病症特点的帕金森病动物模型分析  

Animal Model Analysis of Parkinson’s Disease Based on Clinical Characteristics of Traditional Chinese and Western Medicine

作　　者：樊帅珂 方晓艳[1] 苗明三[1] Fan Shuaike;Fang Xiaoyan;Miao Mingsan(Henan university of traditional Chinese medicine,Henan 450046)

机构地区：[1]河南中医药大学,郑州450046

出　　处：《中药药理与临床》2020年第4期200-204,共5页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家自然科学基金(编号:81274154);中原学者(编号:162101510003);国家国际合作基地(编号:2016-65);国家中医药管理局中医药标准化专项(编号:2017-149-11)。

摘　　要：帕金森病动物模型的建立标准不一,方法不同,但缺少能反映颤证临床病症特点、体现帕金森病中西医病因的动物模型特点的复制方法。本文综述现有的帕金森病动物模型实验研究,对现有动物模型与临床病症的吻合情况进行分析探讨,总结各种模型方法的优点与不足,提出可供帕金森病动物模型参考的建议与评价思路。确立合理的反映帕金森病真实特征的模型是帕金森病动物模型的发展方向,为复制出更贴近临床发病特点的帕金森病模型提出合理的意见。There are different standards and methods for establishing animal models with Parkinson’s disease,but there is no replication method that can reflect the characteristics of clinical symptoms of tremor syndrome and the etiology of traditional Chinese and western medicine in animal models with Parkinson’s disease. This paper summarized the experimental research of existing animal model with Parkinson’s disease, analyzed the coincidence between the existing animal model and clinical disease, summarized the advantages and disadvantages of various model methods,provided suggestions and evaluation ideas for the animal model with Parkinson’s disease. It is the development direction of animal models with Parkinson’s disease to establish reasonable models that reflect the true characteristics of Parkinson’s disease.

关 键 词：中医药 帕金森病 动物模型 多巴胺 Α-突触核蛋白 酪氨酸羟化酶 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R-332[医药卫生—临床医学]