生物医学光学成像的进展与展望  

Progress and prospect of biomedical optical imaging

作　　者：付玲 骆清铭 FU Ling;LUO QingMing(Britton Chance Center for Biomedical Photonics,MoE Key Laboratory for Biomedical Photonics,Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and Technology,Wuhan 430074,China;School of Biomedical Engineering,Hainan University,Haikou 570228,China)

机构地区：[1]华中科技大学武汉光电国家研究中心生物医学光子学教育部重点实验室Britton Chance生物医学光子学研究中心,武汉430074 [2]海南大学生物医学工程学院,海口570228

出　　处：《中国科学：生命科学》2020年第11期1222-1236,共15页Scientia Sinica(Vitae)

基　　金：国家自然科学基金(批准号:81827901,61890952,81971692,61721092);科技部国家重点研究发展计划(批准号:2017YFC0110002)资助。

摘　　要：光学成像与生物医学领域的交叉融通可追溯至17世纪用显微镜观察微生物开始.几个世纪以来,光学成像不断拓展其内涵与外延,因高分辨、多尺度、多维度、易集成以及低辐射等优势,在生物医学领域的基础研究和临床诊疗中展现出源源不断的生命力,为生命科学信息的获取、处理和可视化提供了变革性科学仪器和科学工具,是人类从认识微观生物体结构到理解动态生命过程的创新源泉.本文从生物医学光学成像的发展现状入手,针对生物医学光学成像技术的几个重要方向,分别阐述了其进展与未来发展趋势.The interdisciplinary of optical imaging and biomedical science dates back to the seventeenth century when the first observation of microorganisms with the microscope.Over the centuries,optical imaging has continuously expanded its connotation and extension.Due to its advantages of high resolution,multi-scale,multi-dimensional,low radiation,and easy to integrate,it has shown a steady stream of vitality in the field of biomedical science ranging from basic research to clinical diagnosis and treatments.It provides transformative scientific instruments and tools for the acquisition,processing,and visualization of bioscience information.It is the source of innovation for human beings from observing microscopic biological structures to understanding dynamic life processes.The review starts with the developments of biomedical optical imaging,focusing on several essential directions of imaging technologies,and expounds its progress and future trends.

关 键 词：光学成像 显微成像技术 标记技术 多尺度 多维度 临床应用 人工智能 

分 类 号：R443[医药卫生—诊断学]