曲安奈德与雷珠单抗治疗Ⅱ型视盘血管炎的疗效对比  

Comparison of efficacy between posterior subtenon injection of triamcinolone acetonide and intravitreal injection of ranibizumab for type Ⅱ optic disc vasculitis

作　　者：杨红伟[1] 杨倩倩[1] 刘德成[1] Yang Hongwei;Yang Qianqian;Liu Decheng(Department of Ophthalmology,The 7th People’s Hospital of Zhengzhou,Zhengzhou 450006,China)

机构地区：[1]郑州市第七人民医院眼科,450016

出　　处：《中华眼外伤职业眼病杂志》2020年第10期792-797,共6页Chinese Journal of Ocular Trauma and Occupational Eye Disease

摘　　要：目的比较后部眼球筋膜下注射曲安奈德与玻璃体内注射雷珠单抗治疗Ⅱ型视盘血管炎的效果。方法回顾性分析郑州市第七人民医院2018年5月至2019年5月Ⅱ型视盘血管炎30例(30眼)的临床资料。患者分为两组,每组15例(15眼)。A组行雷珠单抗0.05 ml玻璃体内注射和B组行曲安奈德0.5 ml 40 mg后部眼球筋膜下注射。随访6个月,观察注药后视力、眼压和黄斑中心区厚度。结果两组治疗后视力均较治疗前提高(P<0.05)。注射后1周和6个月黄斑中心区厚度(CMT)、眼压均低于注射前,差异均有统计学意义(P<0.05)。治疗后视力均较治疗前提高(P<0.05)。结论曲安奈德及雷珠单抗治疗Ⅱ型视盘血管炎所致黄斑水肿均有效,术后视力均提高。与雷珠单抗相比,后部眼球筋膜下注射曲安奈德无感染的风险,更加安全可靠。Objective To compare the efficacy between posterior subtenon injection of triamcinolone acetonide(TA)and intravitreal injection of ranibizumab for the treatment of typeⅡoptic disc vasculitis.Methods The clinical data of 30 eyes of 30 patients with typeⅡoptic disc vasculitis from May 2018 to May 2019 in the Seventh People’s Hospital were retrospectively analyzed.All patients were divided into Ranibizumab group and TA group,with 15 eyes of 15 cases in each group.The ranibizumab group received intravitreal injection of 0.05 ml ranibizumab and the TA group received posterior subtenon injection of 40 mg/0.5 ml TA.The visual acuity,intraocular pressure and central macular thickness(CMT)were observed after 6 months follow-up.Results The visual acuity after treatment were improved(P<0.05).The CMT and the mean intraocular pressure at 1 week and 6 months after injection in the two groups were lower than those before injection(P<0.05).There was significant difference in CMT after treatment between the two groups(P>0.05).Conclusion Both triamcinolone acetonide and ranibizumab are effective for the treatment of macular edema caused by type II optic disc vasculitis.The visual acuity of the two groups are improved after treatment.Compared with ranibizumab,triamcinolone acetonide injection in the posterior subtenon space has no risk of infection and is more safe and reliable.

关 键 词：血管炎 视盘 Ⅱ型 曲安奈德 注射 眼球筋膜下 后部 雷珠单抗 注射 玻璃体内 

分 类 号：R774.6[医药卫生—眼科]