Ultrasonic vocalizations in mice: relevance for ethologic and neurodevelopmental disorders studies  

作　　者：Marika Premoli Maurizio Memo Sara Anna Bonini 

机构地区：[1]Department of Molecular and Translational Medicine,University of Brescia,Viale Europa 11,Brescia,Italy

出　　处：《Neural Regeneration Research》2021年第6期1158-1167,共10页中国神经再生研究（英文版）

基　　金：supported by Research Grant from the University of Brescia(to Memo M).

摘　　要：Mice use ultrasonic vocalizations(USVs)to communicate each other and to convey their emotional state.USVs have been greatly characterized in specific life phases and contexts,such as mother isolation-induced USVs for pups or female-induced USVs for male mice during courtship.USVs can be acquired by means of specific tools and later analyzed on the base of both quantitative and qualitative parameters.Indeed,different ultrasonic call categories exist and have already been defined.The understanding of different calls meaning is still missing,and it will represent an essential step forward in the field of USVs.They have long been studied in the ethological context,but recently they emerged as a precious instrument to study pathologies characterized by deficits in communication,in particular neurodevelopmental disorders(NDDs),such as autism spectrum disorders.This review covers the topics of USVs characteristics in mice,contexts for USVs emission and factors that modulate their expression.A particular focus will be devoted to mouse USVs in the context of NDDs.Indeed,several NDDs murine models exist and an intense study of USVs is currently in progress,with the aim of both performing an early diagnosis and to find a pharmacological/behavioral intervention to improve patients’quality of life.

关 键 词：autism spectrum disorders behavioral phenotyping emotional state environmental modulation maternal immune activation mouse models neurodevelopmental disorders social context ultrasonic communication vocalizations classification 

分 类 号：R749.94[医药卫生—神经病学与精神病学]