Prion protein in myelin maintenance: what does the goat say?  

作　　者：Fredrik S.Skedsmo Arild Espenes Michael A.Tranulis 

机构地区：[1]Department of Preclinical Sciences and Pathology,Norwegian University of Life Sciences,Oslo,Norway

出　　处：《Neural Regeneration Research》2021年第6期1216-1217,共2页中国神经再生研究（英文版）

基　　金：supported by grants from the Norwegian University of Life Sciences and The Research Council of Norway(227386/E40).

摘　　要：The cellular prion protein PrPC has been extensively studied because it can adopt a pathogenic three-dimensional conformation that causes rare,but invariably fatal,neurodegenerative prion diseases in humans and other mammals.The disease-causing conformer of the protein is called PrPSc,of which oligomeric aggregates constitute prion agents that can bind to,and convert further,PrPC molecules into PrPSc(Prusiner,1998).Thus,in the poorly understood process of prion propagation,there is transfer of biological information encoded solely by protein conformation.Prions can spread within a tissue secondary to a spontaneous conversion of PrPC to PrPSc or upon transmission of prion agents between individuals.

关 键 词：PRION CONVERT INVAR 

分 类 号：R373[医药卫生—病原生物学]