Thrombin in peripheral nerves:friend or foe?  

作　　者：Elena Pompili Cinzia Fabrizi 

机构地区：[1]Department of Anatomy,Histology,Forensic Medicine and Orthopedics,Sapienza University,Rome,Italy

出　　处：《Neural Regeneration Research》2021年第6期1223-1224,共2页中国神经再生研究（英文版）

基　　金：supported by grants from Sapienza University to CF(RM118164328DF7F2 and RM11916B88BF39BB).

摘　　要：Differently from the central nervous system(CNS),the peripheral nervous system(PNS)exhibits a high regenerative capacity.This ability is related to the remarkable plasticity of Schwann cells(SCs)which after nerve injury convert to a repair-promoting phenotype to a large extent.Nerve injury is accompanied by a rapid rise of thrombin levels(Bushi et al.,2016;Gera et al.,2016).Thrombin is the key effector protease of the coagulation cascade which elicits hormonelike actions by the activation of G-protein coupled receptors known as proteaseactivated receptors(PARs).Inflammation and coagulation are two complex and interconnected pathways whose mutual interactions have been only partially elucidated.

关 键 词：mutual INJURY CONVERT 

分 类 号：R338[医药卫生—人体生理学]