Ischemic colitis after enema administration: Incidence, timing, and clinical features  

作　　者：Yura Ahn Gil-Sun Hong Ju Hee Lee Choong Wook Lee Seon-Ok Kim 

机构地区：[1]Department of Radiology and Research Institute of Radiology,University of Ulsan College of Medicine&Asan Medical Center,Seoul 05505,South Korea [2]Department of Clinical Epidemiology and Biostatistics,Asan Medical Center,University of Ulsan College of Medicine,Seoul 05505,South Korea

出　　处：《World Journal of Gastroenterology》2020年第41期6442-6454,共13页世界胃肠病学杂志（英文版）

摘　　要：BACKGROUND Enema administration is a common procedure in the emergency department(ED). However, several published case reports on enema-related ischemic colitis(IC) have raised the concerns regarding the safety of enema agents. Nevertheless, information on its true incidence and characteristics are still lacking.AIM To investigate the incidence, timing, and risk factors of IC in patients receiving enema.METHODS We consecutively collected the data of all adult patients receiving various enema administrations in the ED from January 2010 to December 2018 and identified patients confirmed with IC following enema. Of 8320 patients receiving glycerin enema, 19 diagnosed of IC were compared with an age-matched control group without IC.RESULTS The incidence of IC was 0.23% among 8320 patients receiving glycerin enema;however, there was no occurrence of IC among those who used other enema agents. The mean age ± standard deviation(SD) of patients with glycerin enemarelated IC was 70.2 ± 11.7. The mean time interval ± SD from glycerin enema administration to IC occurrence was 5.5 h ± 3.9 h(range 1-15 h). Of the 19 glycerin enema-related IC cases, 15(79.0%) were diagnosed within 8 h. The independent risk factors for glycerin-related IC were the constipation score [Odds ratio(OR), 2.0;95% confidence interval(CI): 1.1-3.5, P = 0.017] and leukocytosis(OR, 4.5;95%CI: 1.4-14.7, P = 0.012).CONCLUSION The incidence of glycerin enema-related IC was 0.23% and occurred mostly in the elderly in the early period following enema administration. Glycerin enemarelated IC was associated with the constipation score and leukocytosis.

关 键 词：ENEMA GLYCERIN Ischemic colitis INCIDENCE TIMING Risk factors 

分 类 号：R574.62[医药卫生—消化系统]