医源性胆道良性狭窄动物模型的研究进展  

Research progress of animal model of iatrogenic benign biliary stricture

作　　者：张硕 顾元龙 顾万清[3] Zhang Shuo;Gu Yuanlong;Gu wanqing(Medicial School of Nantong University,Nantong 226001,Jiangsu Province,China;Center of Hepatopancreatobiliary Surgery,the Affiliated Hospital of Jiangnan University(Wuxi No.3 Hospital),Wuxi 214041,China;Department of Hepatobiliary Surgery,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]南通大学医学院,江苏南通226001 [2]江南大学附属医院(无锡三院)肝胆胰中心,无锡214041 [3]解放军总医院第一医学中心肝胆外科,北京100853

出　　处：《中华肝胆外科杂志》2020年第10期797-800,共4页Chinese Journal of Hepatobiliary Surgery

摘　　要：随着腹腔镜胆囊切除等微创手术的普及和发展,医源性胆道损伤和损伤后胆道狭窄的发生率较以前明显增加。腹腔镜胆囊切除的胆道损伤以热损伤为主,热损伤后的胆管组织易发生胆道狭窄。复杂的医源性胆道狭窄的治疗目前仍是一个棘手的、尚未完全解决的问题。要进一步探索医源性胆道狭窄的治疗方法,必须借助于胆道狭窄的动物模型。本文根据国内外文献,就目前几种胆道良性狭窄动物模型的制作方法及其利弊做一综述。With the popularity and development of minimally invasive surgery such as laparoscopic cholecystectomy,the incidence of iatrogenic biliary tract injury and biliary duct stenosis after injury has been increased significantly.The biliary duct injury of laparoscopic cholecystectomy is mainly heat damage,and the biliary duct tissue is prone to biliary duct stenosis after heat injury.Currently the treatment of complex iatrogenic biliary stricture has still been a difficult and unfinished problem.It’s necessary to explore the therapy options of iatrogenic biliary stricture based on animal models of biliary stricture.According to the literature at home and abroad,this article reviewed the methods and advantages and disadvantages of several models of benign biliary stricture.

关 键 词：腹腔镜 胆囊切除术 胆道损伤 胆管狭窄 动物模型 

分 类 号：R-332[医药卫生] R575.7