Nonalcoholic fatty liver disease in lean subjects:Prognosis,outcomes and management  

作　　者：Lampros Chrysavgis Eleftheria Ztriva Adonis Protopapas Konstantinos Tziomalos Evangelos Cholongitas 

机构地区：[1]First Department of Internal Medicine,Medical School,National and Kapodistrian University of Athens,Laiko General Hospital,Athens 11527,Greece [2]First Propedeutic Department of Internal Medicine,Medical School,Aristotle University of Thessaloniki,AHEPA Hospital,Thessaloniki 54636,Greece

出　　处：《World Journal of Gastroenterology》2020年第42期6514-6528,共15页世界胃肠病学杂志（英文版）

摘　　要：Nonalcoholic fatty liver disease(NAFLD)accounts for most cases of chronic liver disease worldwide,with an estimated global prevalence of approximately 25%and ranges from simple steatosis to nonalcoholic steatohepatitis and cirrhosis.NAFLD is strongly connected to metabolic syndrome,and for many years,fatty liver was considered to be an exclusive feature of obese patients.However,recent studies have highlighted the presence of NAFLD in non-obese subjects,with or without increased visceral fat or even in lean subjects without increased waist circumference.“Lean NAFLD”is a relatively new concept and there is significant scientific interest in understanding the differences in pathophysiology,prognosis and management compared with NAFLD in overweight/obese patients.In the present editorial,we discuss the clinical and metabolic profiles and outcomes of lean NAFLD compared with both obese NAFLD and lean healthy individuals from Asian and Western countries.Moreover,we shed light to the challenging topic of management of NAFLD in lean subjects since there are no specific guidelines for this population.Finally,we discuss open questions and issues to be addressed in the future in order to categorize NAFLD patients into lean and nonlean cohorts.

关 键 词：Lean nonalcoholic fatty liver disease Non-obese nonalcoholic fatty liver disease Clinical outcomes Metabolic outcomes Disease management Lifestyle interventions 

分 类 号：R575.5[医药卫生—消化系统]