Role of gut microbiota via the gut-liver-brain axis in digestive diseases  

作　　者：Jian-Hong Ding Zhe Jin Xiao-Xu Yang Jun Lou Wei-Xi Shan Yan-Xia Hu Qian Du Qiu-Shi Liao Rui Xie Jing-Yu Xu 

机构地区：[1]Department of Gastroenterology,Affiliated Hospital to Zunyi Medical University,Zunyi 563003,Guizhou Province,China

出　　处：《World Journal of Gastroenterology》2020年第40期6141-6162,共22页世界胃肠病学杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China,No. 81970541,No. 31960151,No. 81660099 and No. 81660412。

摘　　要：The gut-brain axis is a bidirectional information interaction system between the central nervous system(CNS) and the gastrointestinal tract, in which gut microbiota plays a key role. The gut microbiota forms a complex network with the enteric nervous system, the autonomic nervous system, and the neuroendocrine and neuroimmunity of the CNS, which is called the microbiota-gut-brain axis. Due to the close anatomical and functional interaction of the gut-liver axis, the microbiota-gut-liver-brain axis has attracted increased attention in recent years. The microbiota-gut-liver-brain axis mediates the occurrence and development of many diseases, and it offers a direction for the research of disease treatment. In this review, we mainly discuss the role of the gut microbiota in the irritable bowel syndrome, inflammatory bowel disease, functional dyspepsia, non-alcoholic fatty liver disease, alcoholic liver disease, cirrhosis and hepatic encephalopathy via the gut-liver-brain axis, and the focus is to clarify the potential mechanisms and treatment of digestive diseases based on the further understanding of the microbiota-gut-liver-brain axis.

关 键 词：Microbiota-gut-brain axis Gut-liver axis Gut microbiota Digestive diseases Herbaceous medications 

分 类 号：R57[医药卫生—消化系统]