多巴胺受体D2信号通路在肿瘤发生发展和治疗中的作用  

Roles of Dopamine Receptor D Signaling in Tumorigenesis and Treatment

作　　者：刘玉梅 安输[1] 刘莹[1] 郝倩[1] 郭晓汐 向诚[1] 徐天瑞[1] 杨洋[1] LIU Yumei;AN Shu;LIU Ying;HAO Qian;GUO Xiaoxi;XIANG Cheng;XU Tianrui;YANG Yang(Faculty of Life Science and Technology,Kunming University of Science and Technology,Kunming 650500,China)

机构地区：[1]昆明理工大学生命科学与技术学院,昆明650500

出　　处：《中国细胞生物学学报》2020年第9期1694-1699,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81460417);云南省科技计划(批准号:201901S070097)资助的课题。

摘　　要：多巴胺受体D2(dopamine receptor D2,D2)属于G蛋白偶联受体(G protein-coupled receptor,GPCR)家族成员,其信号通路参与调节细胞分泌和细胞活力,是重要的药物靶点。目前研究显示,D2广泛表达于多种肿瘤细胞,对肿瘤的发生发展和转移具有重要意义。该文就D2在肿瘤发生发展和治疗中的作用进行综述,对其在不同肿瘤中的分布、信号转导和选择性配体进行了小结。Dopamine receptor D2 is a member of the G protein-coupled receptor family.D2 signaling pathway,an important drug target,is involved in the regulation of cell secretion and cell viability.Current studies have shown that D2 is widely expressed in many tumor cells and has important significance to the genesis,development and metastasis of tumor.This review will summarize the role of D2 in tumorigenesis and treatment,as well as the D2 distribution,signal transduction,and selective ligands in different tumors.

关 键 词：D2受体 增殖 转移 信号转导 配体 

分 类 号：R730.5[医药卫生—肿瘤]