六合丹湿敷腹部联合早期益生菌添加肠内营养支持对重症急性胰腺炎患者预后的影响  

Observation of effects of abdominal wet compress of liu-he-dan combined with enteral nutrition support with early probiotics on prognosis of SAP patients

作　　者：夏迪 陈霞 申明 严娅 乔江蓉 XIA Di;CHEN Xia;SHEN Ming;YAN Ya;QIAO Jiang-rong(Department of Gastroenterology,West China Hospital,Sichuan University and West China College of Nursing,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院消化内科/四川大学华西护理学院,四川成都610041

出　　处：《实用医院临床杂志》2020年第6期65-68,共4页Practical Journal of Clinical Medicine

基　　金：四川大学华西医院科研基金资助项目(编号:HXHL19030)。

摘　　要：目的观察六合丹湿敷腹部联合早期益生菌添加肠内营养支持对重症急性胰腺炎(SAP)患者预后的影响观察。方法选取82例SAP患者,按随机数字表法分为观察组与对照组各41例,均给予常规基础治疗,对照组在此基础上给予早期益生菌添加肠内营养支持治疗,观察组在对照组基础上联合六合丹湿敷腹部治疗。比较两组短期(14 d内)临床疗效,记录治疗前、治疗14 d后的病情严重程度评分、炎症因子水平及血清酶学指标变化,并通过死亡率评估预后。结果治疗过程中,两组死亡率比较差异无统计学意义(P=0.356);治疗后,观察组临床治疗总有效率高于对照组(P<0.05);两组Ranson评分、APACHE-II评分、中医证候积分、白介素-6、肿瘤坏死因子-α、C反应蛋白水平及血清淀粉酶、血清谷氨酸氨基转移酶、血清脂肪酶、乳酸脱氢酶水平与治疗前比较差异有统计学意义,且观察组与对照组比较差异有统计学意义(P<0.05)。结论在早期益生菌添加肠内营养支持的基础上联合六合丹湿敷腹部确可有效改善SAP患者临床症状,提高其临床疗效,并有利于炎症因子水平的降低及酶学指标的恢复。Objective To observe the effects of abdominal wet compress of liu-he-dan combined with enteral nutrition support with early probiotics on prognosis of patients with severe acute pancreatitis(SAP).Methods Eighty-two SAP patients were divided into observation or control group according to the random number table method,41 in each group.All patients were given conventional basic treatment,and the control group was given enteral nutrition support with early probiotics on this basis,and the observation group was combined with abdominal wet compress of liu-he-dan on the basis of the control group.The short-term(within 14 days)clinical efficacy was compared between the two groups,and the disease severity scores,inflammatory factors and serum enzyme indexes were recorded before treatment and after 14 days of treatment.The prognosis was evaluated by mortality rate.Results During treatment,there was no statistically significant difference in mortality between the two groups(P=0.356).After treatment,the total effective rate in the observation group was significantly higher than that in the control group(P<0.05).After 14 days of treatment,there were significant differences in the scores of Ranson scoring system,APACHE-II scoring system and TCM syndromes in the two groups when compared with those before treatment(all P<0.05),and there were significant differences between the two group(P<0.05).After 14 days of treatment,there were significant differences in the levels of IL-6,TNF-αand CRP in the two groups when compared with those before treatment(all P<0.05),and there were significant differences between the two group(P<0.05).After 14 d of treatment,there were significant differences in the levels of AMY,ALT,LPS and LDH in the two groups when compared with those before treatment(all P<0.05),and there were significant differences between the two groups(P<0.05).Conclusion The combination of abdominal wet compress of liu-he-dan on the basis of enteral nutrition support with early probiotics can effectively improve the clinical

关 键 词：重症急性胰腺炎 益生菌 肠内营养支持 六合丹 临床疗效 

分 类 号：R576[医药卫生—消化系统]