小剂量普萘洛尔治疗婴幼儿头颈部血管瘤的分析与研究  

Analysis and study of low-dose propranolol in the treatment of hemangioma on infantile head and neck

作　　者：肖富福 田克强 罗克勍 谢鋆晖 曾汶 张相民 XIAO Fu-fu(Head and neck surgery,Ganzhou tumor hospital,Ganzhou,Jiangxi,341000,China)

机构地区：[1]江西省赣州市肿瘤医院头颈科,341000

出　　处：《齐齐哈尔医学院学报》2020年第16期1994-1996,共3页Journal of Qiqihar Medical University

摘　　要：目的评价小剂量普奈洛尔治疗婴幼儿头颈部血管瘤的近期疗效和不良反应。方法选择2013年6月—2018年6月本院收治的34例符合标准的婴幼儿头颈部血管瘤患者为研究对象,早餐后半小时给予顿服普奈洛尔,月龄<2月者剂量为1 mg/(kg·d),月龄>2月者剂量为1.5 mg/(kg·d),服药时及服药后密切观察患儿血管瘤颜色、瘤体大小及质地与初次服药时的变化,服药后观察患儿面色、血压和心率变化;其次观察患儿精神状态、腹泻、睡眠及体重等情况;患儿随访时间为服药后每月随访1次,停药后每月随访1次,至停药后3个月。结果Ⅰ级疗效3例,Ⅱ级疗效7例,Ⅲ级疗效15例,Ⅳ级疗效9例。显效为24例,占比70.58%;不良反应7例,其中腹泻4例,汗多3例,未给予特殊处理,后症状缓解,未出现停药退出病例。结论小剂量普奈洛尔治疗婴幼儿头颈部血管瘤近期疗效确切,可用于婴幼儿增生期血管瘤的治疗;其不良反应目前发现较少且可耐受,仍需增加病例数及延长随访时间。Objective To evaluate the short-term efficacy and side effects of low-dose propranolol in the treatment of hemangioma on infantile head and neck.Methods Thirty-four infants with infantile hemangioma on head and neck,those admitted to our hospital during the period Jun 2016 to June 2018,were selected as study subjects.Half an hour after breakfast,they were given a daily dose of propranolol.The dose of propranolol was 1 mg/(kg·d) for those whose age was less than 2 months,and 1.5 mg/(kg·d) for those whose age was more than 2 months.The changes of the color,size and texture of hemangioma and the changes of their face color,blood pressure and heart rate were observed during and after taking the medicine.Second observe the mental state,diarrhea,sleep and weight of the children.The follow-up time of the children was once a month after taking the medicine,after stopping the medicine,and until three months after stopping the medicine.Results There were 3 cases with grade I effect,7 cases with grade II effect,15 cases with grade III effect and 9 cases with grade IV effect.The excellenceeffective rate was 70.58%(24 cases).Adverse reactions occurred in 7 cases,including 4 cases of diarrhea and 3 cases of sweating,the symptoms were relieved without special treatment,and there was no withdrawal case.Conclusions The short-term effect of low-dose propranolol in the treatment of infantile hemangioma on head and neck is definite,and it could be used in the treatment of infantile proliferative hemangioma,it induces less adverse reactions and presents good tolerable among patients,and it is still necessary to increase the number of cases and extend the follow-up time.

关 键 词：普奈洛尔 婴幼儿 血管瘤 

分 类 号：R739.41[医药卫生—肿瘤]