基于颌骨和股骨差异的动物实验中种植体骨结合影响因素  

Differences in implant osseointegration in the jaw and femur in animal experiments

作　　者：唐渝菲 周安琪 于晖 刘珍珍 张歆缘 王斌[2] 张恺文 向琳[2] TANG Yufei;ZHOU Anqi;YU Hui;LIU Zhenzhen;ZHANG Xinyuan;WANG Bin;ZHANG Kaiwen;XIANG Lin(State Key Labora-tory of Oral Diseases&National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sich-uan University,Chengdu 610041,China;State Key Laboratory of Oral Diseases&National Clinical Research Cen-ter for Oral Diseases,Deptartment of Oral Implantology,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China;Deptartment of Cleft Lip and Palate Surgery,West China Hospital of Stomatology,Sich-uan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院,四川成都610041 [2]口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院种植科,四川成都610041 [3]四川大学华西口腔医院唇腭裂外科,四川成都610041

出　　处：《口腔疾病防治》2021年第1期57-60,共4页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：国家自然科学基金(81701007);四川大学华西口腔医院人才队伍建设科研经费(RCDWJS2020⁃6);中央高校基本科研业务费专项资金(2018SCUH0006);四川大学华西口腔医院基础与应用基础研究项目(RD⁃02⁃201902)。

摘　　要：颌骨和股骨是基础研究中常用的构建骨缺损或植入种植体的部位。越来越多的研究指出,颌骨和股骨二者在胚胎发育及生长、组织形态学结构以及骨代谢等方面存在较大差异。文献复习结果表明与股骨相比,颌骨的骨膜内成骨方式可能具有更优的成骨能力,同时其内的干细胞增殖能力更强,成骨分化能力更好;但颌骨组织结构的规律性欠佳,成骨细胞成骨矿化能力稍弱,免疫细胞对细胞因子更敏感,这些可能是导致动物实验中颌骨与股骨种植体骨结合存在差异的原因,但其具体机制尚未阐明。The jaw and femur are commonly used sites in basic research for modeling bone defects or inserting im⁃plants.An increasing number of studies have identified that the jaw and femur indeed show great differences in embry⁃onic development and growth,histomorphology and bone metabolism.A literature review showed that,compared with the femur,the main osteogenic pathway of the jaw may have better osteogenic ability,and its stem cells have better pro⁃liferation and osteogenic differentiation ability.However,the jaw structure is less regular,the osteogenic differentiation ability of its osteoblasts is mineralization slightly weak,and the immune cells of the jaw are more sensitive to cytokines.These may be the reasons why the osseointegration of the jaw implant is different from that of the femur in animal exper⁃iments,but its specific mechanism has not been clarified.

关 键 词：牙列缺损 口腔种植义齿 骨结合 骨代谢 颌骨 股骨 胚胎发育 组织形态学 

分 类 号：R78[医药卫生—口腔医学]