噬菌体在酒精性肝病治疗中的应用  

Application of bacteriophage technique in the treatment of alcoholic liver disease

作　　者：马欢 佟静[2] 王炳元[2] MA Huan;TONG Jing;WANG Bingyuan(Department of Gastroenterology,The First Affiliated Hospital of Jinzhou Medical University,Jinzhou,Liaoning 121000,China;Department of Gastroenterology,The First Affiliated Hospital of China Medical University,Shenyang 110001,China)

机构地区：[1]锦州医科大学附属第一医院消化内科,辽宁锦州121000 [2]中国医科大学附属第一医院消化内科,沈阳110001

出　　处：《临床肝胆病杂志》2020年第11期2606-2608,共3页Journal of Clinical Hepatology

基　　金：国家青年自然科学基金(8170030364)。

摘　　要：酒精性肝炎是一种严重的酒精相关性肝病,病死率高达40%。最近的一项研究揭示了分泌外毒素(溶细胞素)的肠道细菌粪肠球菌是导致酒精性肝炎的关键因素,可以用噬菌体消除粪肠球菌。因此利用噬菌体治疗酒精性肝炎为临床医师提供了新的治疗方案。介绍这项开创性研究的同时,还进一步介绍了有关噬菌体和溶细胞素的相关知识,为酒精性肝炎的临床研究提供理论基础。Alcoholic hepatitis( AH) is a severe alcohol-associated liver disease with a mortality rate as high as 40%. A recent study reveals that the exotoxin( cytolysin)-secreting gut bacterium Enterococcus faecalis is a critical factor for AH,which can be eliminated by bacteriophages,and therefore,the use of bacteriophages for the treatment of AH provide a new treatment option for AH. This article introduces this pioneering study and the knowledge of bacteriophages and cytolysin,so as to provide a theoretical basis for the clinical research on AH.

关 键 词：肝炎 酒精性 细菌噬菌体 穿孔素 治疗学 

分 类 号：R575.5[医药卫生—消化系统]