mTOR相关信号通路介导的自噬对肝损伤的调控作用  

Regulatory effect of mTOR pathway-mediated autophagy in liver injury

作　　者：黄倩 李京涛 刘永刚 魏海梁 闫曙光[2] 郭英君[5] 常占杰 HUANG Qian;LI Jingtao;LIU Yonggang;WEI Hailiang;YAN Shuguang;GUO Yingjun;CHANG Zhanjie(The First Clinical Medical College,Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712406,China;College of Basic Medicine,Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712406,China;First Department of Hepatology,The Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712406,China;First Department of General Surgery,The Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712406,China;Department of Infectious Disease,The People’s Hospital of Ningxia Hui Autonomous Region,Yinchuan 750001,China)

机构地区：[1]陕西中医药大学第一临床医学院,陕西咸阳712406 [2]陕西中医药大学基础医学院,陕西咸阳712406 [3]陕西中医药大学附属医院肝病一科,陕西咸阳712406 [4]陕西中医药大学附属医院普外一科,陕西咸阳712406 [5]宁夏回族自治区人民医院感染疾病科,银川750001

出　　处：《临床肝胆病杂志》2020年第11期2621-2625,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81603612,81904192);陕西省重点研发计划(2020ZDLSF05-15),陕西省科技厅科研基金(2018KJXX-093);陕西省“特支计划”区域发展人才项目(2017);宁夏回族自治区自然科学基金(NZ17278);陕西中医药大学学科创新团队建设项目(2019-YL05)。

摘　　要：自噬能调节肝脏生理、平衡肝脏代谢。自噬激活对肝损伤的作用是双面、复杂的,受多种因素调控,与多种蛋白通路相关联。总结了mTOR机制靶点在自噬调节中的作用,其通过PI3K/AKT上游信号通路相应地抑制或增强自噬水平,参与相关肝脏疾病的生理病理变化。故而综述mTOR/PI3K/AKT自噬通路在肝损伤方面的研究进展,旨在为相关肝脏疾病提供新的治疗靶点。Autophagy can regulate liver physiology and balance liver metabolism.Autophagy activation has a double-sided and complex effect on liver injury,and it is regulated by many factors and is associated with many protein pathways.This article summarizes the role of mTOR in the regulation of autophagy,which can inhibit or enhance autophagy through the PI3K/Akt upstream signaling pathway and participate in the physiological and pathological changes of related liver diseases.Therefore,this article reviews the research advances in the mTOR/PI3K/Akt autophagy pathway in liver injury,in order to provide new therapeutic targets for related liver diseases.

关 键 词：自噬 肝损伤 哺乳动物雷帕霉素靶蛋白 信号传导 

分 类 号：R575[医药卫生—消化系统]