急性脑梗死合并2型糖尿病患者血清Caveolin-1的水平变化及其与早期神经功能恶化的关系  

The change of serum caveolin-1 level in acute cerebral infarction patients complicated with type 2 diabetes mellitus and its relationship with early neurological deterioration

作　　者：宋文英[1] 赵静[1] 唐浩 苟宁[1] 周娇[1] Song Wenying;Zhao Jing;Tang Hao(Department of Anesthesiology,Shanxi Provincial Hospital,Xi'an 710068)

机构地区：[1]陕西省人民医院麻醉科,西安710068

出　　处：《卒中与神经疾病》2020年第5期580-584,共5页Stroke and Nervous Diseases

基　　金：陕西省自然科学项目(编号为2018JM7110)。

摘　　要：目的探讨急性脑梗死合并2型糖尿病患者血清陷窝蛋白-1(Caveolin-1)的水平变化及其与早期神经功能恶化(END)的关系。方法选择2018年1月-2019年12月本院收治的急性脑梗死合并2型糖尿病患者、急性脑梗死患者、2型糖尿病患者、健康志愿者,检测血清Caveolin-1的水平,评价急性脑梗死合并2型糖尿病患者的END,采用Logistic回归分析END的影响因素,采用ROC曲线分析Caveolin-1水平对END的预测价值。结果急性脑梗死合并2型糖尿病组患者的血清Caveolin-1水平高于急性脑梗死组、2型糖尿病组、对照组(P<0.05);急性脑梗死合并2型糖尿病组END患者的Caveolin-1水平、女性比例、入院时NIHSS评分、起病至入院时间、糖化血红蛋白、随机血糖、hs-CRP水平均高于非END患者(P<0.05);logistics回归分析显示,Caveolin-1水平增高、女性、糖化血红蛋白水平增高及入院时NIHSS评分增加是急性脑梗死合并2型糖尿病组患者END的危险因素(P<0.05);ROC曲线分析显示,血清Caveolin-1对急性脑梗死合并2型糖尿病患者的END具有预测价值,最佳截点为34.95 ng/mL。结论血清Caveolin-1水平升高是急性脑梗死合并2型糖尿病患者END的危险因素,且对END具有预测价值。Objective To study the change of serum caveolin-1 level in acute cerebral infarction patients complicated with type 2 diabetes mellitus and its relationship with early neurological deterioration(END).Methods From January 2018 to December 2019,patients with acute cerebral infarction and type 2 diabetes,patients with acute cerebral infarction,patients with type 2 diabetes and healthy volunteers were selected.Then serum caveolin-1 level was detected,the END of acute cerebral infarction patients complicated with type 2 diabetes mellitus was evaluated,the influencing factors of END was analyzed by logistic regression,and the predictive value of caveolin-1 for END was analyzed by ROC curve.Results The serum caveolin-1 level of acute cerebral infarction complicated with type 2 diabetes mellitus group was higher than those of the acute cerebral infarction group,type 2 diabetes mellitus group and control group(P<0.05).The serum caveolin-1 level,the proportion of female,the NIHSS score on admission,the time from onset to admission,glycosylated hemoglobin,random blood glucose and hs-CRP levels of END patients in acute cerebral infarction complicated with type 2 diabetes mellitus group were all higher than that of non END patients in acute cerebral infarction complicated with type 2 diabetes mellitus group(P<0.05).Logistic regression analysis showed that the increasing of caveolin-1 level,female,the increasing of glycosylated hemoglobin level and NIHSS score at admission were the risk factors of END in acute cerebral infarction patients complicated with diabetes mellitus(P<0.05).ROC curve analysis showed that serum caveolin-1 level had predictive value in END in acute cerebral infarction patients complicated with diabetes mellitus,the best cutoff was 34.95 ng/mL(P<0.05).Conclusion The increasing of serum caveolin-1 level was a risk factor of END in acute cerebral infarction patients complicated with diabetes mellitus,and it had a predictive value for END.

关 键 词：急性脑梗死 2型糖尿病 陷窝蛋白-1 早期神经功能恶化 危险因素 预测 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R587.1[医药卫生—临床医学]