晚期大肠癌患者手术前后免疫功能监测的意义  

Significance of Monitoring the Immune Function of Patients with Advanced Colorectal Cancer before and after Operation

作　　者：杨新书 杜秀坤 李志勇 李艳茹 张秀敏 王建琴 YANG Xin-shu;DU Xiu-kun;LI Zhi-yong;LI Yan-ru;ZHANG Xiu-min;WANG Jian-qin(Oncology Department,Shijiazhuang Luquan People's Hospital,Shijiazhuang,Hebei 050200)

机构地区：[1]石家庄市鹿泉人民医院肿瘤科,河北石家庄050200

出　　处：《智慧健康》2020年第28期9-10,共2页Smart Healthcare

摘　　要：目的探讨晚期大肠癌患者手术前后T淋巴细胞亚群、NK细胞的异常改变及其临床意义。方法应用免疫荧光法和酶联免疫吸附法(ELISA法)对20例健康对照组和31例大肠癌患者手术前后T淋巴细胞亚群、NK细胞检测。结果大肠癌患者CD3^+、CD4^+、CD4^+/CD8^+和NK细胞明显低于健康对照组(P<0.05)。结论手术前后T淋巴细胞亚群、NK细胞的动态监测是反映大肠癌患者免疫功能变化的客观指标,对指导患者的临床治疗有重要的参考价值。Objective To investigate the abnormal changes of T lymphocyte subsets,NK cells in patients with advanced colorectal cancer before and after operation and their clinical significance.Methods immunofluorescence and enzyme-linked immunosorbent assay(ELISA)were used to detect T lymphocyte subsets,NK cells in 20 healthy controls and 31 colorectal cancer patients before and after operation.Results CD3^+,CD4^+,CD4^+/CD8^+and NK cells in patients with colorectal cancer were significantly lower than those in the control group(P<0.05).Conclusion The dynamic monitoring of T-lymphocyte subsets,NK cells before and after operation is an objective index to reflect the changes of immune function in patients with colorectal cancer,which has important reference value for guiding the clinical treatment of patients.

关 键 词：大肠癌 T细胞亚群 CD3^+ CD4^+ NK细胞 

分 类 号：R735.34[医药卫生—肿瘤]