眼部信号转导在近视发病机制中的作用  

New progress of ocular signal transduction in the pathogenesis of myopia

作　　者：徐玉珊 张丰菊 Xu Yushan;Zhang Fengju(Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,BeijingKey Laboratory of Ophthalmology and Visual Sciences,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院,北京同仁眼科中心,眼科学与视觉科学北京市重点实验室,100730

出　　处：《国际眼科纵览》2020年第5期318-323,共6页International Review of Ophthalmology

基　　金：国家自然科学基金(81570877);北京市卫生系统高层次卫生技术人才学科带头人基金(2013-2-023);北京经济技术开发区新创工程领军人才培养基金(20180509)。

摘　　要：我国近视患病率不断上升,为有效防治近视,已有大量研究探索近视的发病机制。既往研究表明近视引起的异常视觉刺激由视网膜神经元接收并产生信号经视网膜色素上皮和脉络膜转导至巩膜,引起巩膜重塑、眼轴延长。然而信号具体如何从视网膜转导至巩膜尚不明确,研究发现TGF-β/Smad、JAK/STAT、视黄酸、PPAR、Wnt/β-catenin、多巴胺、乙酰胆碱受体和GABA等信号通路在信号转导中具有重要作用,信号通路的研究在防治近视方面具有重要的临床价值。With the increasing prevalence of myopia in China,many studies have been done to explore the pathogenesis of myopia to prevent and treat myopia effectively.Previous studies have shown that the abnormal visual stimulation of myopia is detected by retinal neurons,which generates signals through RPE and choroid into sclera,resulting in scleral remodeling and axial elongation.However,it is not clear how signals are transducted from retina to sclera.Studies have found that TGF-β/Smad,JAK/STAT,retinoic acid,PPAR,Wnt/β-catenin,dopamine,acetylcholine receptor and GABA signaling pathways play an important role in transduction,the study of which has significant clinical value in the prevention and treatment of myopia.

关 键 词：近视 信号转导 

分 类 号：R778.11[医药卫生—眼科]