实脾饮联合普萘洛尔治疗肝硬化腹水临床研究  

Clinical Study on Shipi Yin Combiend with Propranolol for Ascites Due to Cirrhosis

作　　者：陈霞 孙杰 汪军亚 杜燕飞 俞建平 CHEN Xia;SUN Jie;WANG Junya;DU Yanfei;YU Jianping

机构地区：[1]杭州市临安区人民医院感染科,浙江杭州311300

出　　处：《新中医》2020年第20期52-55,共4页New Chinese Medicine

摘　　要：目的:观察实脾饮联合普萘洛尔治疗肝硬化腹水的临床疗效。方法:将肝硬化腹水患者74例随机分为2组,各37例。对照组采用普萘洛尔治疗,观察组在对照组的基础上加用实脾饮治疗。2组均持续治疗1个月,观察比较2组临床疗效、腹围、肝功能指标[丙氨酸转氨酶(ALT)、门冬氨酸转氨酶(AST)、总胆红素(TBil)、白蛋白(Alb)]及并发症发生率等。结果:总有效率观察组为94.59%,对照组为75.68%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组患者血清ALT、AST、TBil水平均较治疗前降低(P<0.05),Alb水平升高(P<0.05);且观察组上述各项指标改善较对照组更显著(P<0.05)。治疗后2组腹围均较治疗前明显减小(P<0.05),且观察组腹围明显小于对照组(P<0.05)。腹水相关并发症总发生率观察组为21.62%,对照组为37.84%,2组比较,差异有统计学意义(P<0.05)。结论:实脾饮联合普萘洛尔治疗肝硬化腹水可促进腹水消退,改善肝功能,减少相关并发症。Objective:To observe the clinical effect of Shipi Yin combined with propranolol for ascites due to cirrhosis.Methods:A total of 74 cases of patients with ascites due to cirrhosis were randomly divided into two groups,37 cases in each group.The control group was treated with propranolol,and the observation group was additionally treated with Shipi yin based on the treatment of the control group.Both groups were continuously treated for one month.The clinical effect,abdominal circumference,the incidence of complications,as well as the levels of alanine aminotransferase(ALT)and aspartate aminotransferase(AST),total bilirubin(TBil)and albumin(Alb)for evaluating the liver function were observed and compared between the two groups.Results:The total effective rate was 94.59%in the observation group and 75.68%in the control group,the difference being significant(P<0.05).After treatment,the levels of ALT,AST and TBil in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of Alb were increased(P<0.05);the improvement of the above four indexes in the observation group was more significant than that in the control group(P<0.05).After treatment,the abdominal circumference in the two groups was significantly decreased when compared with that before treatment(P<0.05),and the circumference in the observation group was significantly smaller than that in the control group(P<0.05).The total incidence of ascites-related complications was 21.62%in the observation group and 37.84%in the control group,the difference being significant(P<0.05).Conclusion:The therapy of Shipi Yin combined with propranolol in treating ascites due to cirrhosis can promote ascites disappearance,improve the liver function,and reduce the incidence of related complications.

关 键 词：肝硬化腹水 脾肾阳虚证 实脾饮 普萘洛尔 

分 类 号：R575.2[医药卫生—消化系统]