Survivin shRNA-APC双基因对结肠癌细胞中MCM2表达影响的研究进展  

The Research Progressof Survivin shRNA APC Double Gene on MCM2 Expression in Colon Cancer Cells

作　　者：孙元佳 陈月 张玉健 张楚悦 李昂嫣 袁喜先 Sun Yuanjia;Chen Yue;Zhang Yujian;Zhang Chuyue;Li angyan;Yuan Xixian(School of Clinical Medicine,Jiamusi University 154007,China;The First Affiliated Hospital of Jiamusi University,Jiamusi 154003,China)

机构地区：[1]佳木斯大学临床医学院,黑龙江佳木斯154007 [2]佳木斯大学附属第一医院,黑龙江佳木斯154003

出　　处：《山东化工》2020年第20期54-54,60,共2页Shandong Chemical Industry

摘　　要：研究证实,APC、Survivin基因异常表达对结肠癌有重要意义,本课题探讨Survivin shRNA-APC双基因共表达稳转株对结肠癌HT-29细胞中MCM2表达的影响,通过检测MCM2的表达,更深入了解双基因对结肠癌HT-29细胞的影响。通过进一步究为结肠癌未来靶向治疗提供相应的基础实验依据,MCM2有望成为检测结肠癌的靶向指标。Studies have confirmed that the abnormal expression of APC and Survivin genes is of great significance to colon cancer.This topic explores the effect of stable co-expression of Survivin shRNA-APC gene on the expression of MCM2 in colon cancer HT-29 cells.By detecting the expression of MCM2,we can further understand the effect of dual genes on colon cancer HT-29 cells.Through further research to provide the corresponding basic experimental basis for the future targeted therapy of colon cancer,MCM2 is expected to become a target indicator for the detection of colon cancer.

关 键 词：双基因 结肠癌 MCM2 

分 类 号：R735.35[医药卫生—肿瘤]