A型肉毒毒素治疗三叉神经痛和带状疱疹后神经痛的临床疗效  

Clinical study on the treatment of trigeminal neuralgia and post-herpetic neuralgia with botulinum toxin type A

作　　者：李华亮[1] 潘平雷[1] 陈佳慧[1] 罗容[1] 沈媛[1] 钟建国[1] LI Hua-liang;PAN Ping-lei;CHEN Jia-hui;LUO Rong;SHEN Yuan;ZHONG Jian-guo(Department of Neurology, the Third People’s Hospital of Yancheng, Yancheng 224005, Jiangsu, China)

机构地区：[1]盐城市第三人民医院神经内科,盐城224005

出　　处：《中国临床医学》2020年第5期834-836,共3页Chinese Journal of Clinical Medicine

摘　　要：目的:观察A型肉毒毒素治疗三叉神经痛和带状疱疹后神经痛的临床效果。方法:选取33例三叉神经痛或带状疱疹后神经痛患者,进行疼痛区域A型肉毒毒素皮下或皮内注射治疗,评估患者治疗时、治疗2周后、治疗3个月后疼痛情况(NRS)、睡眠状况及生活质量(QOL),判断治疗效果,观察药物不良反应。结果:患者使用A型肉毒毒素治疗2周后、3个月后疼痛评分、睡眠评分显著低于治疗时(P<0.05),生活质量显著高于治疗时(P<0.05),治疗效果好,不良反应少。结论:A型肉毒毒素治疗三叉神经痛和带状疱疹后神经痛效果显著,可成为神经病理性疼痛治疗的一种新途径。Objective:To observe the clinical effect of botulinum toxin type A(BTX-A)on trigeminal neuralgia(TN)and post-herpetic neuralgia(PHN).Methods:Thirty-three patients with TN or PHN were treated by subcutaneous or intradermal injection of BTX-A into the pain area,the patients’numerical rating scale(NRS),sleep status and quality of life(QOL)at the time of treatment,2 weeks after treatment,and 3 months after treatment were evaluated,the treatment effect and the drug adverse reactions were analyzed.Results:After 2 weeks and 3 months of treatment with BTX-A,NRS and sleep score of the patients were significantly lower than those at the time of treatment(P<0.05),QOL was significantly higher than that at the time of treatment(P<0.05).Treatment effect was good and few side effects were observed.Conclusions:BTX-A is effective in treating TN and PHN and can become a new therapeutic approach for neuropathic pain.

关 键 词：A型肉毒毒素 三叉神经痛 带状疱疹后神经痛 

分 类 号：R745.11[医药卫生—神经病学与精神病学]