视网膜α-crystallins在增生性视网膜疾病中的研究进展  

Research progress of retinalα-crystallins in proliferative retinal diseases

作　　者：徐雅慧 袁源智 XU Ya-hui;YUAN Yuan-zhi(Department of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai 200032, China)

机构地区：[1]复旦大学附属中山医院眼科,上海200032

出　　处：《中国临床医学》2020年第5期866-870,共5页Chinese Journal of Clinical Medicine

基　　金：国家自然科学基金(81970817,81873680).

摘　　要：α-crystallins是小分子热休克蛋白家族(small-molecule heat shock protein,sHSP)的重要成员,包括αA-crystallin和αB-crystallin,在各类组织细胞中具有细胞保护和分子伴侣功能。近年来,多项研究发现,视网膜组织α-crystallins可利用自身特性通过各种途径参与增生性视网膜病的血管新生、上皮/内皮细胞间质化等过程。本文主要介绍α-crystallins,尤其是αB-crystallin调节增生性视网膜疾病发展的分子机制,探讨其潜在的临床应用价值。α-crystallins are an important member of the small-molecule heat shock protein family(sHSP),includingαA-crystallin andαB-crystallin,which have cytoprotection and molecular chaperone functions in various cells and tissues.In recent years,it has been found that retinalα-crystallins are involved in proliferative retinal diseases via regulating angiogenesis and epithelial/endothelial-mesenchymal transition.This article introduces the specific mechanism ofα-crystallins,especiallyαB-crystallin,in regulating the development of proliferative retinal diseases,and its potential clinical application.

关 键 词：α-crystallins 糖尿病视网膜病 黄斑变性 玻璃体视网膜病变 血管生成 上皮间质化转变 

分 类 号：R774.1[医药卫生—眼科]