兰索拉唑联合血凝酶治疗消化性溃疡合并出血的临床效果研究  

Clinical effect of lansoprazole combined with haemocoagulase atrox in the treatment of peptic ulcer complicated with hemorrhage

作　　者：朱小霞 ZHU Xiao-xia(Department of Internal Medicine,Dezhou United Hospital,Dezhou 253000,China)

机构地区：[1]山东省德州市联合医院内科,253000

出　　处：《中国现代药物应用》2020年第21期127-129,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析兰索拉唑联合血凝酶治疗消化性溃疡合并出血的临床效果。方法选择98例消化性溃疡合并出血患者作为研究对象,随机分为对照组和观察组,每组49例。观察组患者采用兰索拉唑联合血凝酶治疗,对照组患者采用奥美拉唑联合血凝酶治疗。比较两组患者的止血效果、出血量减少时间、止血时间及不良反发生情况。结果治疗后,观察组患者的止血总有效率为97.96%(48/49),对照组患者的止血总有效率为85.71%(42/49),观察组患者的止血总有效率高于对照组,差异具有统计学意义(P<0.05)。观察组患者的出血量减少时间为(0.18±0.12)h,止血时间为(1.19±0.34)h,均短于对照组的(0.39±0.17)、(2.35±0.71)h,差异具有统计学意义(P<0.05)。观察组患者的不良反应发生率为18.37%(9/49),对照组患者的不良反应发生率为36.73%(18/49),观察组患者的不良反应发生率低于对照组,差异具有统计学意义(P<0.05)。结论在消化性溃疡合并出血患者的治疗过程中,兰索拉唑联合血凝酶的治疗方式具有较好的效果,可明显缩短患者的止血时间,安全性较高,在临床上有很高的应用价值。Objective To analyze the clinical effect of lansoprazole combined with haemocoagulase atrox in the treatment of peptic ulcer complicated with hemorrhage.Methods A total of 98 cases of peptic ulcer complicated with hemorrhage as study subjects were randomly divided into control group and observation group,with 49 cases in each group.The observation group was treated with lansoprazole combined with haemocoagulase atrox,and the control group was treated with omeprazole combined with haemocoagulase atrox.The hemostasis effect,reduction time of blood volume,hemostasis time and occurrence of adverse reactions were compared between the two groups.Results After treatment,the total effective rate of hemostasis of the observation group was 97.96%(48/49),which was 85.71%(42/49)of the control group.The total effective rate of hemostasis of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The reduction time of blood volume(0.18±0.12)h and hemostasis time(1.19±0.34)h of the observation group were shorter than(0.39±0.17)and(2.35±0.71)h of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions of the observation group was 18.37%(9/49),which was 36.73%(18/49)of the control group,and the incidence of adverse reactions of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Lansoprazole combined with haemocoagulase atrox has good effect and high practical value in the treatment of patient with peptic ulcer complicated with hemorrhage,which can obviously shortern hemostasis time with high safety.

关 键 词：兰索拉唑 血凝酶 消化性溃疡合并出血 

分 类 号：R573.1[医药卫生—消化系统]