血清甲胎蛋白、高尔基体蛋白73、α-L-岩藻糖苷酶、血清铁蛋白联合检测在原发性肝癌早期诊断中的价值  

The value of serum alpha-fetoprotein,golgi protein 73,α-L-fucosidase and serum ferritin in combination in early diagnosis of primary liver cancer

作　　者：郁淼[1] 秦兵[1] 胡道军[1] 张莉[1] YU Miao;QIN Bing;HU Daojun;ZHANG Li(Department of Laboratory Medicine,Chongming Branch of Xinhua Hospital Affiliated to Medical College of Shanghai Jiaotong University,Shanghai,202150)

机构地区：[1]上海交通大学医学院附属新华医院崇明分院检验科,上海202150

出　　处：《实用临床医药杂志》2020年第20期37-39,43,共4页Journal of Clinical Medicine in Practice

基　　金：上海市科学技术委员会科研项目(11DZ1931500)。

摘　　要：目的探讨血清甲胎蛋白(AFP)、高尔基体蛋白73(GP73)、α-L-岩藻糖苷酶(AFU)、血清铁蛋白(SF)联合检测在原发性肝癌早期诊断中的价值。方法将收治的34例原发性肝癌患者作为观察组,并选取同时期收治的35例良性肝脏病变患者作为对照组。比较2组血清AFP、GP73、AFU、SF水平及联合检测情况。结果观察组血清AFP、GP73、AFU、SF水平与对照组比较,差异均有统计学意义(P<0.05)。观察组TNMⅢ~Ⅳ期血清AFP、GP73、AFU、SF水平与TNMⅠ~Ⅱ期比较,差异均有统计学意义(P<0.05)。血清AFP、GP73、AFU、SF联合检测的诊断敏感度为91.18%、准确度为82.61%,均高于单项检测,差异有统计学意义(P<0.05)。结论血清AFP、GP73、AFU、SF联合检测可显著提高诊断敏感度、准确度,对原发性肝癌诊断具有重要价值。Objective To explore the value of serum alpha-fetoprotein(AFP),golgi protein 73(GP73),α-L-fucosidase(AFU)and serum ferritin(SF)in the early diagnosis of primary liver cancer.Methods A total of 34 patients with primary liver cancer were selected as observation group,and a total of 35 patients with benign liver disease were selected as control group.The serum levels of AFP,GP73,AFU as well as SF and the condition of combined detection were compared between the two groups.Results The serum levels of AFP,GP73,AFU and SF in the observation group showed significant difference when compared with the control group(P<0.05).The serum levels of AFP,GP73,AFU and SF in the observation group in stages ofⅢtoⅣof TNM classification showed significant difference when compared with those in stages ofⅠtoⅡof TNM classification(P<0.05).The sensitivity and accuracy of serum AFP,GP73,AFU and SF in combination were 91.18%and82.61%,respectively,which were higher than the single detection,and the differences were statistically significant(P<0.05).Conclusion The combined detection of serum AFP,GP73,AFU and SF can significantly improve the sensitivity and accuracy,which is of great value in the diagnosis of primary liver cancer.

关 键 词：原发性肝癌 血清标志物 单项检测 联合检测 糖蛋白 良性病变 

分 类 号：R735.7[医药卫生—肿瘤]