特应性皮炎的皮肤微生态和微生物组学研究进展  

Advances in human skin microecology and microbiome in atopic dermatitis

作　　者：林颖[1,2,5] 罗海敏 郑敏玲 李文均[3] 屈平华[1,4,5] Lin Ying;Luo Haimin;Zheng Minling;Li Wenjun;Qu Pinghua(Department of Dermatology,Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510006,China;The Second Clinical Medical College,Guangzhou University of Chinese Medicine,Guangzhou 510006,China;School of Life Sciences,Sun Yat-Sen University,Guangzhou 510275,China;Department of Clinical Laboratory,Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510006,China;Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases,Guangzhou 510120,China)

机构地区：[1]广东省中医院大学城医院皮肤科,广州510006 [2]广州中医药大学第二临床医学院,510006 [3]中山大学生命科学学院,广州510275 [4]广东省中医院检验医学部,广州510006 [5]广东省中医药防治难治性慢病重点实验室,广州510120

出　　处：《中华微生物学和免疫学杂志》2020年第10期800-806,共7页Chinese Journal of Microbiology and Immunology

基　　金：广东省中医药防治难治性慢病重点实验室(2018B030322012);国家自然科学基金(31972856)。

摘　　要：特应性皮炎(atopic dermatitis,AD)是一种好发于儿童和青少年的慢性、复发性、瘙痒性皮肤疾病,其发病率呈逐年增高的趋势。AD发病机制复杂,与遗传、环境、免疫、皮肤屏障功能障碍等多方面因素有关。近年来,宏基因组学和代谢组学等高通量技术为探讨AD的发病机制打开了新的视角,并在探索AD的菌群移植新疗法中展现了诱人的应用前景。本文从皮肤微生态与人体皮肤健康的关系、AD发病机制、AD微生组学研究和相关的病原微生物特征、AD微生物疗法展望等方面进行阐述,并结合自身的实践经验,提出AD的培养组学研究方案,以及皮肤标本微生物学检验和定量计数的设想,从而为AD的疾病预防、疗效监测和临床治疗等提供参考。Atopic dermatitis(AD)is a chronic,relapsable and pruritic skin disease,commonly found in children and adolescents.The prevalence of AD is increasing worldwide.It is reported that AD is related to many factors such as genetic inheritance,environment,immunity and skin barrier dysfunction,suggesting a very complex pathogenesis.In recent years,high-throughput technologies in the field of genomics and metabolomics have opened up new perspectives on the pathogenesis of AD,and shown potential application prospects in microbiome transplantation therapies for AD.This review summarized the current advances in the relationship between skin microecology and skin health,the pathogenesis and microbiomic characteristics of AD,features of pathogenic microorganisms,and microbiome transplantation therapies for AD.Based on our own practical experience,we put forward a culturomics research protocol to study the human skin microbiome and a method for quantitative microbiological examination,aiming to provide reference for the prevention,clinical treatment and therapeutic monitoring of AD.

关 键 词：特应性皮炎 皮肤微生态 皮肤菌群 微生物学检验 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]